Protection afforded by a herbal medicine, Sho-seiryu-to (TJ-19), against oleic acid-induced acute lung injury in guinea-pigs

Yang, C.Q. and Ishitsuka, Y. and Moriuchi, H. and Golbidi, S. and Jin, Z.J. and Irikura, M. and Irie, T. (2009) Protection afforded by a herbal medicine, Sho-seiryu-to (TJ-19), against oleic acid-induced acute lung injury in guinea-pigs. Journal of Pharmacy and Pharmacology, 61 (7). pp. 925-932.

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Objectives: The effect of a herbal medicine, Sho-seiryu-to (TJ-19), on oleic acid-induced lung injury, an animal model of acute respiratory distress syndrome or acute lung injury (ARDS/ALI), was examined. Methods: Acute lung injury was induced by an intravenous injection of 15 μl/kg oleic acid to guinea-pigs. TJ-19 was administered by a single oral dose (3 g/kg) or by multiple oral doses (0.75 g/kg). Key findings: The decrease in partial oxygen pressure of arterial blood (Pao2) and the increase in airway vascular permeability induced by the oleic acid injection were attenuated by a single dose of TJ-19. When TJ-19 was administered orally twice a day for two weeks and then oleic acid was injected, a potent prophylactic effect of the drug was observed. TJ-19 also prevented airway vascular hyperpermeability, lung cell injury, oxidative stress and thromboxane A2 generation, associated with the oleic acid injection. Conclusions: TJ-19 significantly attenuated the oleic acid-induced lung injury probably through the antioxidative effect and inhibitory effect of thromboxane A2 generation, although the precise inhibitory mechanisms were not fully elucidated due to the diversity in constituents of the herbal medicine. We suggest that TJ-19 is a promising drug candidate and a medicinal resource for preventing ARDS/ALI. © 2009 The Authors.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: lactate dehydrogenase; oleic acid; sho seiryu to; thromboxane A2; tj 19; unclassified drug; herbaceous agent; sho seiryu to; sho-seiryu-to; thromboxane A2, acute lung injury; adult respiratory distress syndrome; animal experiment; animal model; arterial blood; article; blood gas analysis; blood vessel permeability; cell damage; controlled study; drug effect; enzyme activity; guinea pig; herbal medicine; high performance liquid chromatography; lung injury; lung lavage; male; nonhuman; oxidative stress; oxygen tension; acute lung injury; animal; biosynthesis; capillary permeability; chemically induced disorder; disease model; drug antagonism; medicinal plant; phytotherapy, Acute Lung Injury; Animals; Capillary Permeability; Disease Models, Animal; Drugs, Chinese Herbal; Guinea Pigs; Herbal Medicine; Male; Oleic Acid; Oxidative Stress; Phytotherapy; Plants, Medicinal; Thromboxane A2
Subjects: Medicine
Divisions: Faculty of Medicine > Basic Sciences > Department of physiology
Depositing User: editor . 2
Date Deposited: 08 Jan 2017 16:17
Last Modified: 08 Mar 2017 21:35

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