Effects of Zinc Supplementation on Serum Zinc and C-Reactive Protein Concentrations in Hemodialysis Patients

Rashidi, A.A. and Salehi, M. and Piroozmand, A. and Sagheb, M.M. (2009) Effects of Zinc Supplementation on Serum Zinc and C-Reactive Protein Concentrations in Hemodialysis Patients. Journal of Renal Nutrition, 19 (6). pp. 475-478.

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Objective: We examined the effects of zinc supplementation on serum zinc and C-reactive protein concentrations in hemodialysis patients. Design: This was a randomized, double-blinded, placebo-controlled clinical trial. Setting: This study was conducted at the Shahid Faghihi and Namazi Dialysis Centers in Shiraz, Iran. Patients: Fifty-five hemodialysis patients (32 men and 23 women) participated after meeting the following criteria: zinc deficiency, treated for a minimum of 6 months; no record of hospitalizations in the preceding 3 months; and hemodialysis treatment 2 to 3 times per week. Intervention: Patients were randomly divided into two groups. The zinc supplementation group (n = 28) received a 220-mg zinc sulfate capsule, and the control group (n = 27) received a placebo capsule (220 mg corn starch), for 42 days. Main Outcome Measures: Fasting, predialysis serum samples were collected on days 0 and 42 to determine serum zinc and C-reactive protein levels. Results: After supplementation, subjects in the zinc-supplemented group showed significant increases in serum zinc concentrations, from 57.4 ± 2.4 μg/dL SEM on day 0 to 88.4 ± 4.8 μg/dL SEM on day 42. Serum C-reactive protein concentrations were initially high among subjects in the control (15.1 ± 3.9 mg/L SEM) and zinc-supplemented (13.5 ± 3.8 mg/L SEM) groups. Serum C-reactive protein concentrations in the control group increased throughout the study period, but did not reach statistical significance. A progressive decrease in serum C-reactive protein concentrations was observed in the zinc-supplemented group from the beginning (13.5 ± 3.8 mg/L SEM) to the end (10.5 ± 3.5 mg/L SEM) of the study, but this event was not significant. Conclusion: Zinc supplementation intake may cause an increase in serum zinc concentrations, leading to a decrease of inflammation in hemodialysis patients. © 2009 National Kidney Foundation, Inc.

Item Type: Article
Additional Information: cited By 15
Uncontrolled Keywords: astringent agent; C reactive protein; zinc; zinc sulfate, article; blood; chronic kidney failure; clinical trial; controlled clinical trial; controlled study; diet supplementation; double blind procedure; female; human; male; metabolism; middle aged; randomized controlled trial; renal replacement therapy, Astringents; C-Reactive Protein; Dietary Supplements; Double-Blind Method; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Zinc; Zinc Sulfate, Zea mays
Subjects: Medicine
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 08 Jan 2017 16:23
Last Modified: 11 Mar 2017 14:42
URI: http://eprints.kaums.ac.ir/id/eprint/947

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