Oral versus nasal vasopressin in the treatment of nocturnal enuresis in 5- to 12-year-old children

Taghavi-Ardakani, A. and Honarpisheh, A. and Fakharian, E. and Talebian, A. and Jamali, M. and Moosavi, G.A. and Sadat, Z. and Honarpisheh, P. (2010) Oral versus nasal vasopressin in the treatment of nocturnal enuresis in 5- to 12-year-old children. Iranian Journal of Child Neurology, 4 (1). pp. 13-16. ISSN 1735-4668

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Abstract

Objective Nocturnal enuresis is a common childhood problem and has various treatments. This study was carried out to compare oral and nasal vasopressin in the treatment of nocturnal enuresis in 5- to 12-year-old children who were referred to the Shahid Beheshti Clinic in 2008. Materials & Methods This study included 100 children (62 males and 38 females) with nocturnal enuresis. One group (50 patients) received 20 mcg nasal vasopressin which increased up to 40 mcg, depending on the patients' response. The other group (50 patients) received 0.2 mg oral vasopressin which increased up to 0.4 mg. The patients were followed up for one month after response to the last dose of drug. Data were recorded in prepared forms and analyzed using Chi-Square and Fisher Test. Results The success rate with oral and nasal method was 80 and 92, respectively (P=0.08). Only 2 of the children had complications during the treatment; one child treated orally developed gastroenteritis and another child treated with the nasal method developed convulsions (P=1). Sixteen percent of the children treated with the oral method and 28 of the children treated with the nasal method had recurrence (P=0.148). Conclusion Oral and nasal forms of vasopressin have equal therapeutic effects. However, oral form of the treatment has fewer serious side effects and is easier to use. Therefore, the use of oral medicine is recommended.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: vasopressin, chi square distribution; child; childhood disease; clinical effectiveness; clinical trial; controlled clinical trial; controlled study; convulsion; drug dose increase; drug efficacy; drug safety; female; Fisher exact test; gastroenteritis; human; hyponatremia; major clinical study; male; nocturnal enuresis; preschool child; randomized controlled trial; recurrent disease; review; school child; treatment response
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Pediatrics
Depositing User: editor . 2
Date Deposited: 28 Jan 2017 17:08
Last Modified: 04 Mar 2017 06:21
URI: http://eprints.kaums.ac.ir/id/eprint/920

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