Evaluation of natural killer cell activity in pre and post treated breast cancer patients

Piroozmand, A. and Hassan, Z.M. (2010) Evaluation of natural killer cell activity in pre and post treated breast cancer patients. Journal of Cancer Research and Therapeutics, 6 (4). pp. 478-481.

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Aim: To evaluate natural killer (NK) cells activity in breast cancer patients and its comparison with normal individuals. Settings and Design: Breast cancer is the most prevalent type of spontaneous tumor in humans, and NK cells are the first line defense against such tumors. There is a reverse correlation between NK activity and metastasis and reducing the tumor mass by surgery may be monitoring the NK activity. In this study, we evaluate NK activity in pre and post mastectomy patients. Materials and Methods: Eighteen patients with invasive ductal carcinoma attended to cancer research institute were included in this study. NK cells were evaluated in pre and post mastectomy patients. PBMCs were isolated by ficoll hypaque. NK cell activity ( lysis of K562) was evaluated by flowcytometer. Statistical Analysis Used: One way analysis of variation (ANOVA) and KruskalWallis nonparametric test were employed using SPSS software. Results: While NK cell activity was greatly impaired in breast cancer patients (average lysis of K562 target cells: 24.4 vs. 62.5 in healthy controls, n = 18), it was found to be significantly increased after mastectomy (37.7). Conclusions: Mastectomy may lead to increased activity of NK cells among patients suffering from breast cancer and their increased activity may produce positive therapeutic effect.

Item Type: Article
Additional Information: cited By 9
Uncontrolled Keywords: ficoll, adult; article; blood sampling; cancer patient; cancer research; cancer staging; cell isolation; cell strain K 562; cell viability; clinical article; controlled study; cytolysis; cytotoxicity; female; flow cytometry; human; human cell; intraductal carcinoma; mastectomy; natural killer cell; peripheral blood mononuclear cell; treatment outcome, Adult; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Flow Cytometry; Humans; Killer Cells, Natural; Mastectomy; Middle Aged
Subjects: Immunology and Microbiology
Divisions: Faculty of Medicine > Basic Sciences > Department of Microbiology & Immunology
Depositing User: editor . 2
Date Deposited: 26 Feb 2017 10:51
Last Modified: 11 Mar 2017 14:43
URI: http://eprints.kaums.ac.ir/id/eprint/906

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