Sarbolouki, S. and Djalali, M. and Dorosty, A.R. and Djazayery, S.A. and Eshraghian, M.R. and Ebadi, S.A. and Hashemi, S.B. (2010) Effects of EPA and vitamin E on serum enzymatic antioxidants and peroxidation indices in patients with type II diabetes mellitus. Iranian Journal of Public Health, 39 (3). pp. 82-91.
Full text not available from this repository.Abstract
Background: Diabetes mellitus is associated with chronic changes in peripheral arteries because of oxidative stress and insufficient antioxidative defense mechanism. Omega-3 fatty acid supplementation could be effective in some diabetes complications; however, polyunsaturated fatty acids may increase lipid peroxidation. This study aimed to determine whether eicosapentaenoic acid alone or in conjunction with vitamin E had differential effects on serum antioxidants and peroxidation indices. Methods: This double-blind, placebo-controlled trial was carried out on 136 patients with type II diabetic mellitus (age 48.8±4.4 yr, BMI 27.8±1.7 kg/m2). The four groups of the study either received two grams of omega-3 fatty acids, 400 IU of vitamin E, a combination of the two or placebo for three months. Their serum total antioxidant capacity, enzymatic antioxidants and peroxidation indices were assessed. Result: Fasting serum TAC increased in EPA+E (10.7, P< 0.001) and E groups (7.5, P< 0.05). SOD, G-PX and G-RD increased in EPA group (7.3, 5.1, and 8.4, P< 0.05, respectively). MDA and protein carbonyl decreased in EPA and E groups (respectively, 12.5, 7.6 P< 0.05, P< 0.05; 13, 15.3 P< 0.001, P< 0.05). After adjustment for baseline values, age, sex, BMI and duration of diagnosed diabetes, protein carbonyl decreased in EPA+E and E group (30.7, 15.3; P< 0.05 respectively) relative to the placebo group. Conclusion: EPA, by itself has a statistically significant effect on serum total antioxidant capacity, enzymatic antioxidants and peroxidation indices in diabetic patients compared to EPA+E or E alone.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 8 |
| Subjects: | Medicine |
| Divisions: | Faculty of Medicine > Clinical Sciences > Department of Internal Medicine |
| Depositing User: | editor . 2 |
| Date Deposited: | 26 Feb 2017 09:59 |
| Last Modified: | 12 Mar 2017 13:45 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/898 |
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