Involvement of central amygdala NMDA receptor mechanism in morphine state-dependent memory retrieval

Ardjmand, A. and Rezayof, A. and Zarrindast, M.R. (2011) Involvement of central amygdala NMDA receptor mechanism in morphine state-dependent memory retrieval. Neuroscience Research, 69 (1). pp. 25-31.

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In the current study, the effects of intra-central amygdala (CeA) administration of N-methyl-d-aspartate (NMDA) and its competitive antagonist, d-2-amino-5-phosphonopentanoic acid (D-AP5), on morphine state-dependent memory retrieval were investigated. Post-training subcutaneous (s.c.) administration of different doses of morphine (0.5, 2.5, 5 and 7.5. mg/kg) dose-dependently impaired memory. The response induced by post-training morphine (7.5. mg/kg) was reversed by pre-test administration of this drug (5 and 7.5. mg/kg), indicating morphine state-dependent memory retrieval. Pre-test intra-CeA administration of NMDA (0.01 and 0.05μg/rat) plus an ineffective dose of morphine (0.5. mg/kg, s.c.) restored memory impairment caused by post-training morphine (7.5. mg/kg). However, pre-test intra-CeA administration of NMDA (0.005-0.05μg/rat), alone, was ineffective on post-training morphine-induced amnesia. Furthermore, pre-test intra-CeA administration of the same doses of NMDA had no effect on memory retrieval. Pre-test intra-CeA administration of D-AP5 (0.1-1.0μg/rat) decreased morphine state-dependent memory retrieval. However, pre-test administration of D-AP5 (0.1-1μg/rat) alone decreased memory retrieval, but restored post-training morphine-induced amnesia. In conclusion, our results suggest which CeA may be potentially critical for morphine state-dependent memory retrieval and that CeA NMDA receptor mechanism(s) interact with the opiodergic system in the modulation of morphine state-dependent memory retrieval. © 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society.

Item Type: Article
Additional Information: cited By 10
Uncontrolled Keywords: 2 amino 5 phosphonovaleric acid; morphine sulfate; n methyl dextro aspartic acid; n methyl dextro aspartic acid receptor, amnesia; amygdaloid nucleus; animal experiment; animal model; article; controlled study; dose response; drug dose; learning; male; memory consolidation; mouse; nonhuman; priority journal, 2-Amino-5-phosphonovalerate; Amnesia; Amygdala; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Male; Memory; Memory Disorders; Morphine; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate
Subjects: Neuroscience
Divisions: Faculty of Medicine > Basic Sciences > Department of physiology
Depositing User: editor . 2
Date Deposited: 27 Feb 2017 04:57
Last Modified: 04 Mar 2017 05:48

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