Vitamin-D-free regimen intensifies the spatial learning deficit in Alzheimer's disease

Taghizadeh, M. and Djazayery, A. and Salami, M. and Eshraghian, M.R. and Talaei, S.A. (2011) Vitamin-D-free regimen intensifies the spatial learning deficit in Alzheimer's disease. International Journal of Neuroscience, 121 (1). pp. 16-24.

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Evidences support a link between nutrition and risk of neurodegenerative Alzheimer's disease (AD). This work was designed to find out if food regimens lacking vitamin D or with a supplement of vitamin D could affect spatial performances in the Alzheimeric animals. The experiment was done on the control and Alzheimeric (ALZ) animals on a normal regimen of food, as well as the Alzheimeric rats fed with regimens lacking vitamin D (ALZ-D) or supplemented with 1,25(OH)2D3 (ALZD). For learning the spatial task the animals were trained to locate a hidden platform in the Morris water maze. We found that the ALZ rats had an obvious lower performance compared with the control ones. Generally, the ALZ-D rats displayed a poorer spatial learning compared with either the ALZ or the ALZD rats. Vitamin D supplement did not significantly influence the spatial performance. We conclude that although vitamin D deficiency strengthens the spatial learning deficit in AD, a supplement of 1,25(OH)2D3 does not effectively underlie the maze performance. It can be concluded that subjects with AD must be protected from vitamin D inadequacy.

Item Type: Article
Additional Information: cited By 17
Uncontrolled Keywords: calcium; vitamin D, Alzheimer disease; animal experiment; animal model; article; calcium blood level; controlled study; drug effect; learning disorder; learning test; male; maze test; nonhuman; rat; spatial memory; task performance; vitamin supplementation, Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcitriol; Calcium; Disease Models, Animal; Male; Maze Learning; Rats; Rats, Wistar; Space Perception; Vitamin D Deficiency; Vitamins
Subjects: Neuroscience
Divisions: Faculty of Medicine > Basic Sciences > Department of physiology
Depositing User: editor . 2
Date Deposited: 27 Feb 2017 04:54
Last Modified: 28 Feb 2017 15:30

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