Could the endogenous opioid, morphine, prevent neural stem cell proliferation?

Shoae-Hassani, A. and Sharif, S. and Mortazavi-Tabatabaei, S.A. and Verdi, J. (2011) Could the endogenous opioid, morphine, prevent neural stem cell proliferation? Medical Hypotheses, 76 (2). pp. 225-229.

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In spite of widespread use of morphine to treat pain in patients, little is known about the effects of this opioid on many cells including stem cells. Moreover the studies have been shown controversial results about morphine effects on several kinds of cells. It is well-known that morphine exposure could decrease testosterone levels in brain and spinal cord. Morphine could increase the activity of 5α-redutase, the enzyme that converts testosterone into its respective 5α-redutase derivative dihydrotestosterone (DHT). Also it could increase aromatase activity that converts testosterone to estradiol. Proliferation of neural stem cells was observed in human stem cells after exposure to certain combinations of steroids especially testosterone. On the other hand DHT has negative effect in neural stem cell reproduction. Morphine induces over-expression of p53 gene that could mediate stem cell apoptosis. Therefore we hypothesized that due to reduction in the testosterone levels, elevation in the DHT levels, and over-expression of p53 gene, morphine could prevent neural stem cell proliferation. © 2010 Elsevier Ltd.

Item Type: Article
Additional Information: cited By 10
Uncontrolled Keywords: androstanolone; morphine; opiate; protein p53; steroid 5alpha reductase; testosterone, apoptosis; article; cell proliferation; down regulation; gene; human; neural stem cell; nonhuman; protein expression; testosterone blood level, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Apoptosis; Cell Proliferation; Dihydrotestosterone; Genes, p53; Humans; Models, Biological; Morphine; Neural Stem Cells; Neurodegenerative Diseases; Rats; Regeneration; Testosterone
Subjects: Neuroscience
Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: editor . 2
Date Deposited: 27 Feb 2017 06:02
Last Modified: 08 Mar 2017 21:38

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