Antihyperglycemic and antioxidant activity of Viscum album extract

Shahaboddin, M.E. and Pouramir, M. and Moghadamnia, A.A. and Lakzaei, M. and Mirhashemi, S.M. and Motallebi-Kashani, M. (2011) Antihyperglycemic and antioxidant activity of Viscum album extract. African Journal of Pharmacy and Pharmacology, 5 (3). pp. 432-436.

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Abstract

The antihyperglycemic and antioxidant effects of water extract of local Viscum album in alloxanizedrats were investigated. This study performed during 2009 in Babol University of medical sciences (Mazandaran Province, Iran). V. album leaves growing on oaks collected and extracted with hot water. The 90 animals that were used in this investigation were male Wistar rats. 60 rats were gavaged with 500 and 1000 mg/kg/day of V. album extract. One hour after final feeding, freshly prepared alloxan injected subcutaneously. Then blood glucose level was measured according to glucose oxidase method. The antioxidant activity of serum was determined by FRAP assay and serum insulin level was measured with ELISA. The administration of V. album extract (500 and 1000 mg/kg/day) significantly reduced the increase in serum glucose concentration in alloxan-hyperglycemic rats. Both the extracts from V. album enhance the serum insulin level as compared to control rats. Serum antioxidant activity in low dose of extract was significantly higher at 48 and 72 h after alloxan injection. Serum antioxidant activity in the high dose was significantly higher at 24, 48 and 72 h. This study demonstrated that V. album extract reduced the blood glucose and increases the antioxidant power of alloxanized-rats. Much more work is clearly needed before phytotherapy for diabetes can be advanced to the clinic. © 2011 Academic Journals.

Item Type: Article
Additional Information: cited By 7
Uncontrolled Keywords: alloxan; glucose; glucose oxidase; insulin; Viscum album extract; water, alloxan diabetes mellitus; animal experiment; animal model; antioxidant activity; article; controlled study; drug dose comparison; drug megadose; enzyme linked immunosorbent assay; fluorescence recovery after photobleaching; glucose blood level; glycemic control; hyperglycemia; insulin blood level; Iran; low drug dose; male; nonhuman; plant leaf; rat; treatment outcome; Viscum album
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: editor . 2
Date Deposited: 27 Feb 2017 05:52
Last Modified: 03 Jun 2017 14:10
URI: http://eprints.kaums.ac.ir/id/eprint/870

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