Rashidi, A.A. and Noureddini, M. (2011) Hypoglycemic effect of the aromatic water of leaves of ficus carica in normal and streptozotocin induced diabetic rats. Pharmacologyonline, 1. pp. 372-379.
Full text not available from this repository.Abstract
Diabetes mellitus is the most important metabolic disorder worldwide. Use of medicinal plants for lowering blood glucose is clinically important in diabetic individuals. In this respect, the effect of oral administration of aromatic water of leaves of Ficus carica on blood glucose level in diabetic rats was investigated. In this experimental study, male rats Sprague Dawley (n=80, 200-250 g), divided into two groups (40 normal and 40 diabetic surviving rats), each consisting of four subgroups (4 normal and 4 diabetic) including 10 animals each. Diabetic rats received streptozotocin (ip, 65 mg/kg). Subgroup one of each group was gavaged with vehicle (distilled water) and served as control, while subgroups 2, 3 and 4 of each group were gavaged with aromatic water of leaves of Ficus carica(extract) at doses of 0.05, 0.1, and 0.4 mg/dl, respectively. Blood glucose levels were measured 0, 3, 6, 12 and 24 hours after the administration of vehicle or the extract. Data were analyzed using repeated measure ANOVA and Dunnett t-test. In normal rats at 12 and 24 hours after the administration of 0.05 and 0.1 mg/dl extract, blood glucose level decreased significantly. However, dose of 0.4 mg/dl of extract lowered blood glucose level significantly throughout the experiment. In diabetic rats at 3,6,12 hours after the administration, 0.1 and 0.4 mg/dl of extract decreased blood glucose levels meaningfully. At hour 24, only 0.4 mg/dl of extract lowered blood glucose levels significantly. Our results show that the oral consumption of aromatic water leaves of Ficus carica decreased blood glucose level in normal and diabetic rats.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | antidiabetic agent; ficus carica extract; glucose; plant extract; unclassified drug; water, animal experiment; animal model; article; controlled study; diabetes mellitus; dose response; dose time effect relation; drug effect; drug mechanism; drug screening; Ficus; ficus carica; glucose blood level; male; nonhuman; plant leaf; rat; streptozocin diabetes |
| Subjects: | Nutrition Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Faculty of Medicine > Basic Sciences > Department of physiology |
| Depositing User: | editor . 2 |
| Date Deposited: | 27 Feb 2017 05:35 |
| Last Modified: | 01 Mar 2017 13:53 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/865 |
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