DHEA provides a microenvironment for endometrial stem cells neurogenesis

Shoae-Hassani, A. and Mortazavi-Tabatabaei, S.A. and Sharif, S. and Rezaei-Khaligh, H. and Verdi, J. (2011) DHEA provides a microenvironment for endometrial stem cells neurogenesis. Medical Hypotheses, 76 (6). pp. 843-846.

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Recently, transplantation of adult stem cells over embryonic stem cells increased in regenerative medicine. Among the adult stem cells, human endometrium stromal (hEnS) cells are under the strict control of the steroid hormones and have the potential to differentiate into other cell lineages including neural cells. Unfortunately these cells may lose their neurogenic differentiation ability upon extended expansion in cultures. To avoid the back-differentiation, it is important to establish growth conditions that support the rapid proliferation and stable differentiation of hEnS cells over extended periods of time without compromising their neuronal phenotype. Differentiation of transplanted cells is strongly influenced by environmental signals. The steroidal microenvironment of the stem cells plays a major role in controlling neurogenesis in the cultures. Dehydroepiandrosterone (DHEA) administration to the cultures could support this propose. DHEA enhance survival rates of dissociated neurons in cultures. It can activate AKT protein kinase pathway as well as nerve growth factor (NGF) that enhances neurogenesis efficiently. On the other hand it seems that DHEA increase survival rate of neural cells via production of brain derived neurotrophic factor (BDNF), indirectly. BDNF is a mediator product of the DHEA that promotes the differentiation and survival of neurons. Here, we offer that DHEA is a suitable candidate that could provide a microenvironment to stimulate neurogenesis and enhanced survival of newly formed neurons derived from hEnS cells. From the point that DHEA is the most abundant steroid in the body, marketed as a supplement and is increasingly self-prescription we hypothesized that it could be the safe and high available choice. This provides a better insight into the maintenance of neural cells for treatment of a wide variety of neurological diseases such as Alzheimer's and Parkinson's by non-invasively autologous cell therapy by hEnS cells especially in women. © 2011 Elsevier Ltd.

Item Type: Article
Additional Information: cited By 16
Uncontrolled Keywords: brain derived neurotrophic factor; nerve growth factor; prasterone; protein kinase B, adult stem cell; article; cell proliferation; cell survival; culture medium; endometrium; hormone action; human; hypothesis; microenvironment; nerve cell differentiation; phenotype; stem cell expansion; stroma cell; survival rate, Dehydroepiandrosterone; Endometrium; Female; Humans; Neurogenesis; Stem Cells
Subjects: Medicine
Divisions: Faculty of Medicine > Basic Sciences > Department of physiology
Depositing User: editor . 2
Date Deposited: 27 Feb 2017 08:02
Last Modified: 08 Mar 2017 21:37
URI: http://eprints.kaums.ac.ir/id/eprint/860

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