Detection of ESBLs and MDR in pseudomonas aeruginosa in a tertiary-care teaching hospital

Tavajjohi, Z. and Moniri, R. (2011) Detection of ESBLs and MDR in pseudomonas aeruginosa in a tertiary-care teaching hospital. Iranian Journal of Clinical Infectious Diseases, 6 (1). pp. 18-23.

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Background: Pseudomonas aeruginosa is characterized as an important nosocomial pathogen with increasing antimicrobial resistance. The multidrug-resistant (MDR) phenotype in P. aeruginosa is increasing worldwide. The purpose of this study was to evaluate the prevalence of antibiotic susceptibility, ESBLs (Extended spectrum beta lactamases) producing and multidrug resistant (MDR) P. aeruginosa, isolated from clinical specimens of patients and environment of hospital. Patients and methods: This descriptive study was carried out on 76 isolates of P. aeruginosa from a 500-bed tertiarycare general teaching hospital in Kashan, Iran in 2010. Susceptibility testing according to the CLSI (Clinical Laboratory Standards Institute) recommended to eight antipseudomonal agents was performed. ESBLs producing strains were confirmed by double disk diffusion method. Multidrug-resistant isolates were defined as those resistant to three or more classes of antipseudomonal agents. Results: The highest resistance rates from the isolated P. aeruginosa were shown against piperacillin, imipenem, cefotaxime, ceftriaxone, gentamicin, ceftazidime, aztreonam, and ciprofloxacin, respectively. Seven isolates (9.2) were ESBL producers. More than 30 of the isolates were resistant to at least three classes of antibiotics, and 13 of MDR strains were resistant to all eight tested classes of antimicrobials. Among the total isolates, 6.6 were susceptible to all studied agents, and 9.2 were resistant to a single agent. The isolated bacteria from the tracheal samples showed the highest MDR rate. Conclusion: Prevalence of P. aeruginosa producing ESBL and MDR strains from our clinical samples and environment is still low. © 2011 IDTMRC, Infectious Diseases and Tropical Medicine Research Center.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: antiinfective agent; aztreonam; cefotaxime; ceftazidime; ceftriaxone; ciprofloxacin; extended spectrum beta lactamase; gentamicin; imipenem; penicillin G, antibiotic resistance; antibiotic sensitivity; article; bacterium detection; bacterium isolation; clinical evaluation; concentration response; controlled study; disk diffusion; Iran; multidrug resistance; nonhuman; Pseudomonas aeruginosa; teaching hospital; tertiary health care; urinalysis
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Microbiology & Immunology
Depositing User: editor . 2
Date Deposited: 27 Feb 2017 09:43
Last Modified: 08 Mar 2017 23:19

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