CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer

Vaghari-Tabari, Mostafa and Hassanpour, Parisa and Sadeghsoltani, Fatemeh and Malakoti, Faezeh and Alemi, Forough and Qujeq, Durdi and Asemi, Zatollah and Yousefi, Bahman (2022) CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer. Cellular and Molecular Biology Letters, 27 (1).

Full text not available from this repository. DOI: UNSPECIFIED


The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and archaea. Various studies have shown that it is possible to target a wide range of human genes and treat some human diseases, including cancers, by the CRISPR/Cas9 system. In fact, CRISPR/Cas9 gene editing is one of the most efficient genome manipulation techniques. Studies have shown that CRISPR/Cas9 technology, in addition to having the potential to be used as a new therapeutic approach in the treatment of cancers, can also be used to enhance the effectiveness of existing treatments. Undoubtedly, the issue of drug resistance is one of the main obstacles in the treatment of cancers. Cancer cells resist anticancer drugs by a variety of mechanisms, such as enhancing anticancer drugs efflux, enhancing DNA repair, enhancing stemness, and attenuating apoptosis. Mutations in some proteins of different cellular signaling pathways are associated with these events and drug resistance. Recent studies have shown that the CRISPR/Cas9 technique can be used to target important genes involved in these mechanisms, thereby increasing the effectiveness of anticancer drugs. In this review article, studies related to the applications of this technique in overcoming drug resistance in cancer cells will be reviewed. In addition, we will give a brief overview of the limitations of the CRISP/Cas9 gene-editing technique.

Item Type: Article
Uncontrolled Keywords: CRISPR/Cas9,Cancer treatment,Chemoresistance,Gene editing,Malignancy
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Depositing User: editor . 5
Date Deposited: 04 Apr 2023 12:07
Last Modified: 04 Apr 2023 12:07

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