Similar efficacy of vancomycin and teicoplanin in treatment of catheter related infection in hemodialysis patients

Tamadon, M.R. and Soliemani, A. and Yarmohamadi, M. and Semnani, V. and Ghorbani, R. and Malek, F. and Malek, M. (2012) Similar efficacy of vancomycin and teicoplanin in treatment of catheter related infection in hemodialysis patients. Koomesh, 14 (1). pp. 33-38.

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Abstract

Introduction: Catheter related infection is one of the most important complications of vascular access devices. Treatment of these complications is important and life saving. The most common causative organisms are gram-positive bacteria especially staphylococcus. Vancomycin and teicoplanin are two antibiotics which widely used for invasive beta-lactam-resistant Gram-positive infections. In this study, we aimed to compare efficacy of vancomycin and teicoplanin in treatment of catheter related infection. Material and Methods: In this clinical trial, 43 patients with catheter infection were enrolled. Diagnosis was based on clinical criteria. 22 patients were received teicoplanin 800mg intra-venous loading dose and 400mg at days 2th, 3th,5th,12th,19th and 21 patients received vancomycin 1gr intra venous loading dose and 500mg every 5 days and for 3 weeks. A criterion for treatment response was absence of fever after 72 hours. Results: 57.1 patients who received vancomycin and 68.2 patients who received teicoplanin had clinical response (p=0.454). In patients who received vancomycin, one case developed red man syndrome and one case developed diarrhea (9.5) and in tiecoplanin group one patient developed rash (9.1). Conclusion: Our findings show that there is no significant difference between two groups in treatment of catheter related infection in hemodialysis patients.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: teicoplanin; vancomycin, Article; catheter infection; clinical article; clinical trial; diarrhea; drug efficacy; hemodialysis patient; human; rash; red man syndrome; syndrome
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Internal Medicine
Depositing User: editor . 2
Date Deposited: 27 Feb 2017 10:09
Last Modified: 08 Mar 2017 21:35
URI: http://eprints.kaums.ac.ir/id/eprint/807

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