The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

Maleki Dana, Parisa and Sadoughi, Fatemeh and Asemi, Zatollah and Yousefi, Bahman (2022) The role of polyphenols in overcoming cancer drug resistance: a comprehensive review. Cellular and Molecular Biology Letters, 27 (1).

Full text not available from this repository. DOI: UNSPECIFIED


Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery. However, cancers often develop resistance against drugs, leading to failure of treatment and recurrence of the disease. Polyphenols are a family of organic compounds with more than 10,000 members which have a three-membered flavan ring system in common. These natural compounds are known for their beneficial properties, such as free radical scavenging, decreasing oxidative stress, and modulating inflammation. Herein, we discuss the role of polyphenols (mainly curcumin, resveratrol, and epigallocatechin gallate EGCG) in different aspects of cancer drug resistance. Increasing drug uptake by tumor cells, decreasing drug metabolism by enzymes (e.g. cytochromes and glutathione-S-transferases), and reducing drug efflux are some of the mechanisms by which polyphenols increase the sensitivity of cancer cells to chemotherapeutic agents. Polyphenols also affect other targets for overcoming chemoresistance in cancer cells, including cell death (i.e. autophagy and apoptosis), EMT, ROS, DNA repair processes, cancer stem cells, and epigenetics (e.g. miRNAs).

Item Type: Article
Uncontrolled Keywords: Chemoresistance,Curcumin,Epigallocatechin gallate,Polyphenols,Resveratrol
Subjects: Nutrition
Pharmacology, Toxicology and Pharmaceutics
Depositing User: editor . 5
Date Deposited: 04 Apr 2023 11:21
Last Modified: 04 Apr 2023 11:21

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