Lithium attenuates pain-related behavior in a rat model of neuropathic pain: Possible involvement of opioid system

Banafshe, H.R. and Mesdaghinia, A. and Arani, M.N. and Ramezani, M.H. and Heydari, A. and Hamidi, G.A. (2012) Lithium attenuates pain-related behavior in a rat model of neuropathic pain: Possible involvement of opioid system. Pharmacology Biochemistry and Behavior, 100 (3). pp. 425-430.

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Lithium is a major drug for bipolar disorder and mania. Recently, many studies have shown the neuroprotective effect of lithium in different models of neurodegenerative diseases. The present study was carried out to examine the effect of lithium in a rat model of neuropathic pain induced by partial sciatic nerve ligation and the possible role of opioid system in this effect. To do so, animals received acute injection of saline, lithium (5, 10 and 15 mg/kg,) and naloxone (1 mg/kg) or the combination of naloxone (1 mg/kg) with lithium (10 mg/kg) intraperitoneally on the testing days. Thermal hyperalgesia, mechanical and cold allodynia were measured on the days 3, 5, 7, 10 and 14 after surgery. Lithium decreased thermal hyperalgesia scores with dose of 5, 10 and 15 mg/kg and cold and mechanical allodynia scores with dose of 10 and 15 mg/kg, significantly. The opioid antagonist naloxone prevented the effect of lithium on thermal hyperalgesia and mechanical allodynia while it did not show any effect on the acetone-induced cold allodynia. Our results suggest that lithium can be considered as a therapeutic potential for the treatment of some aspects of neuropathic pain and that the opioid system may be involved in the lithium-induced attenuation of thermal hyperalgesia and mechanical allodynia. © 2011 Elsevier Inc. All rights reserved.

Item Type: Article
Additional Information: cited By 16
Uncontrolled Keywords: lithium; naloxone; opiate receptor, allodynia; animal experiment; animal model; article; cold allodynia; controlled study; drug mechanism; hyperalgesia; male; mechanical allodynia; nerve ligation; neuropathic pain; nonhuman; priority journal; protein function; rat; sciatic nerve; thermal hyperalgesia, Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Lithium Chloride; Male; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Neuralgia; Neuroprotective Agents; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sciatic Nerve, Animalia; Rattus
Subjects: Medicine
Divisions: Faculty of Medicine > Basic Sciences > Department of physiology
Depositing User: editor . 2
Date Deposited: 27 Feb 2017 10:02
Last Modified: 27 Feb 2017 10:02

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