Human serum protein adsorption onto synthesis nano-hydroxyapatite

Mohsen-Nia, M. and Massah Bidgoli, M. and Behrashi, M. and Mohsen-Nia, A. (2012) Human serum protein adsorption onto synthesis nano-hydroxyapatite. Protein Journal, 31 (2). pp. 150-157.

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Abstract

Adsorption of human serum proteins (Albumin and total protein) onto high purity synthesis nano-hydroxyapatite (HA), Ca 10(PO 4) 6(OH) 2, has been studied in a wide temperature range by UV-visible spectrophotometer. Adsorption isotherm is basically important to describe how solutes interact with adsorbent, andiscriticalinoptimizing the use of adsorbent. Inthe present study, the experimental results werefitted tothe Langmuir, Freundlich, Temkin and Dubinin-Radushkevich (DR) models to obtain the characteristic parameters of each model and square of the correlation coefficients (R 2). According to the results, the DR isotherm model had the best agreement with the experimental data. The effect of temperature on adsorption of human serum proteins (HSP) onto the synthesized nano-HA was studied. The experimental results indicated that temperature increase generally causes an increase in the adsorption of HSP onto the nano-HA. This is basically due to the effect of temperature on the HSP activity and its diffusion rate on HA surfaces. © Springer Science+Business Media, LLC 2011.

Item Type: Article
Additional Information: cited By 8
Uncontrolled Keywords: hydroxyapatite; nanomaterial, adsorption; article; female; human; human experiment; isotherm; male; normal human; protein synthesis; serum; spectrophotometer; temperature; ultraviolet radiation, Adsorption; Blood Proteins; Diffusion; Drug Carriers; Durapatite; Female; Humans; Kinetics; Male; Models, Molecular; Nanoparticles; Serum; Serum Albumin; Spectrophotometry; Surface Properties; Temperature
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Clinical Sciences > Department of , Obstetrics & Gynecology
Depositing User: editor . 2
Date Deposited: 28 Feb 2017 15:34
Last Modified: 28 Feb 2017 15:34
URI: http://eprints.kaums.ac.ir/id/eprint/796

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