Anti-nociceptive effect of black seed oil on an animal model of chronic constriction injury

Talaei, Sayyed and Banafshe, Hamid and Moravveji, Alireza and Shabani, Mohammad and Tehrani, Shiva and Abed, Alireza (2022) Anti-nociceptive effect of black seed oil on an animal model of chronic constriction injury. Research in Pharmaceutical Sciences, 17 (4). pp. 383-391.

Full text not available from this repository. DOI: UNSPECIFIED

Abstract

Background and purpose: Traditionally, Nigella sativa L. has been known as a medical intervention to treat numerous diseases. This study aimed at investigating the antihyperalgesic effect of black seed oil (BSO) in an experimental model of neuropathic pain. Experimental approach: Chronic constriction injury (CCI) was performed under anesthesia. The sciatic nerve was ligated with four loose ties. Two separate protocols were used to administer BSO. In chronic treatment, rats were given daily doses of BSO (250, 500, and 1000 mg/kg p.o.) from the 1 st day until the 21 st post-CCI day. While, in acute treatment, BSO (250, 500, and 1000 mg/kg p.o.) was administered only on the 7 th, 14 th, and 21 st days. CCI and sham groups were given almond oil according to the same schedule. Behavioral scores were determined by evaluation of the paw withdrawal in the plantar, Von Frey, and acetone tests, on the 7 th, 14 th, and 21 st days. Findings/Results: Our results showed that CCI leads to significant allodynia and hyperalgesia in the ipsilateral paw after surgery. Chronic administration of BSO (500 and 1000 mg/kg) obviously attenuated heat hyperalgesia and mechanical allodynia. However, daily administration of BSO did not alter cold allodynia. Nevertheless, when BSO was administered, 30 min before the pain assessment tests, hypersensitivity was not improved in the treated animals. Conclusion and implications: These results demonstrated BSO can inhibit neuropathic pain progression and suggests a potential use of BSO to manage hyperalgesia and allodynia. However, additional research is necessary to approve BSO effectiveness, in neuropathic pain conditions.

Item Type:	Article
Subjects:	Pharmacology, Toxicology and Pharmaceutics
Depositing User:	editor . 5
Date Deposited:	04 Apr 2023 09:00
Last Modified:	04 Apr 2023 09:00
URI:	http://eprints.kaums.ac.ir/id/eprint/7915

Actions (login required)

View Item