Combined Administration of Melissa officinalis and Boswellia serrata Extracts in an Animal Model of Memory

Mahboubi, M. and Taghizadeh, M. and Talaei, S.A. and Takhtfiroozeh, S.M. and Rashidi, A.A. and Tamtaji, O.R. (2016) Combined Administration of Melissa officinalis and Boswellia serrata Extracts in an Animal Model of Memory. Iranian Journal of Psychiatry and Behavioral Sciences, 10 (3).

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Abstract

Background: Boswellia serrata and Melissa officinalis is traditionally used for its memory enhancing effects. Objectives: In this study, we evaluated the protective effects of combined form of these extracts onmemory improvement of scopolamine treated rats by the Morris water maze method. MaterialsandMethods: Twogroups (group 1and2) of animals were pretreated withcombinedextracts of B. serrataandM. officinalis (200, 400 mg/Kg body weight) for four weeks and then, 30 minutes before starting the experiment scopolamine was injected (0.1 mg/kg body weight) intraperitoneally to pretreated animals. The control group was the animals that were injected by scopolamine and pre treated with distilled water (group 3). The normal group was treated with distilled water alone (group 4). Results: For time spent and distance, there was no substantial difference between groups 1, 2 and 4, while they had statistical difference with group 3 (P = 0.001). The spatial memory evaluation showed no significant difference between treated groups and normal group. Conclusions: Therefore, the combination of the two extracts had the ability to improve memory as its traditional use. © 2016, Mazandaran University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons.

Item Type: Article
Additional Information: cited By 0
Subjects: Neuroscience
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 04 Mar 2017 08:02
Last Modified: 04 Mar 2017 08:02
URI: http://eprints.kaums.ac.ir/id/eprint/79

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