Evaluation of high-sensitivity C-reactive protein in acute asthma

Razi, E. and Ehteram, H. and Akbari, H. and Chavoshi, V. and Razi, A. (2012) Evaluation of high-sensitivity C-reactive protein in acute asthma. Tanaffos, 11 (1). pp. 32-37.

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Background: High sensitivity C-reactive protein (hs-CRP) is an inflammatory marker known to be related to inflammation, infection, and cardiovascular diseases. The aim of this study was to evaluate hs-CRP level in serum of asthmatics and its relationship with pulmonary function tests, serum IgE levels, and peripheral blood white blood cell (WBC) counts. Materials and Methods: The under study subjects were 108 patients with acute asthma and 93 healthy volunteers. The levels of hs-CRP of 108 patients with acute bronchial asthma and 93 non-asthmatic control subjects were measured. Spirometry, serum immunoglobulin-E (IgE) measurement, and WBC counts were done for patient and control groups. Results: The mean serum hs-CRP levels were significantly higher in patients with acute asthma compared with controls (5.47±7.33 mg/l versus 1.46± 1.89 mg/l, p<0.001). Among asthmatic patients, mean hs-CRP levels were not correlated with indices of pulmonary function tests (forced expiratory volume in one second, forced vital capacity and forced mid-expiratory flow), serum IgE level, eosinophil count or WBC count. Conclusion: Serum C-reactive protein levels measured by high-sensitivity assays increase in acute asthma and may be useful as a diagnostic tool for detecting and monitoring inflammation in these patients. In our study on patients with acute asthma, no significant correlation was revealed between hs-CRP and pulmonary function tests, total serum IgE, or peripheral blood white blood cell counts. © 2012 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: beta 2 adrenergic receptor stimulating agent; C reactive protein; immunoglobulin E, adult; article; asthma; controlled study; disease severity; eosinophil count; female; forced expiratory volume; forced vital capacity; human; immunoglobulin blood level; leukocyte count; lung function test; major clinical study; male; protein blood level; sensitivity and specificity; spirometry
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Internal Medicine
Depositing User: editor . 2
Date Deposited: 28 Feb 2017 15:00
Last Modified: 28 Feb 2017 15:00
URI: http://eprints.kaums.ac.ir/id/eprint/789

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