A randomized comparative trial on the therapeutic efficacy of topical aloe vera and calendula officinalis on diaper dermatitis in children

Panahi, Y. and Sharif, M.R. and Sharif, A. and Beiraghdar, F. and Zahiri, Z. and Amirchoopani, G. and Marzony, E.T. and Sahebkar, A. (2012) A randomized comparative trial on the therapeutic efficacy of topical aloe vera and calendula officinalis on diaper dermatitis in children. The Scientific World Journal, 2012.

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Abstract

Introduction. Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of Aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in children. Methods. Sixty-six infants with DD (aged 3 years) were randomized to receive either Aloe cream (n = 32) or Calendula ointment (n = 34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial. Results. Although improvement in the severity of DD was observed in both treatment groups (P 0.001), patients receiving Calendula ointment had significantly fewer rash sites compared to Aloe group (P = 0.001). No adverse effect was reported from either of the medications. Discussion. The evidence from this study suggests that topical Aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants. Copyright 2012 Yunes Panahi et al.

Item Type: Article
Additional Information: cited By 14
Uncontrolled Keywords: Aloe vera extract; calendula officinalis extract; plant extract; unclassified drug; olive oil; plant extract; vegetable oil, absence of side effects; Aloe vera; article; child; childhood disease; controlled study; cream; diaper dermatitis; disease severity; double blind procedure; drug efficacy; drug safety; female; human; infant; infant disease; major clinical study; male; marigold; medicinal plant; ointment; preschool child; randomized controlled trial; rash; treatment outcome; Aloe; Calendula; chemistry; clinical trial; comparative study; controlled clinical trial; drug administration; emulsion; flower; hospitalization; intradermal drug administration; ointment; phytotherapy; prevalence, Aloe; Aloe vera; Calendula; Calendula officinalis, Administration, Cutaneous; Aloe; Calendula; Child, Preschool; Diaper Rash; Double-Blind Method; Drug Administration Schedule; Emulsions; Female; Flowers; Humans; Infant; Male; Ointments; Phytotherapy; Plant Extracts; Plant Oils; Plants, Medicinal; Prevalence; Severity of Illness Index
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Pediatrics
Depositing User: editor . 2
Date Deposited: 28 Feb 2017 16:12
Last Modified: 28 Feb 2017 16:12
URI: http://eprints.kaums.ac.ir/id/eprint/779

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