Bagheri, Soheil and Saghazade, Ahmad Reza and Abbaszadeh-Mashkani, Samira and Banafshe, Hamid Reza and Ghoreishi, Fatemeh Sadat and Mesdaghinia, Azam and Ghaderi, Amir (2022) The effect of vitamin D supplementation on tobacco-related disorders in individuals with a tobacco use disorder: a randomized clinical trial. Journal of Addictive Diseases, 40 (3). pp. 382-393.
Full text not available from this repository. DOI: UNSPECIFIEDAbstract
Vitamin D deficiency in cigarette smokers (CS) might associate with several complications, including metabolic deficits, depression and anxiety. This study evaluated the effects of vitamin D on mental health symptoms, nicotine misuse, and biomarkers of metabolic diseases in individuals with a tobacco use disorder. A randomized, double-blind, placebo-controlled trial was conducted with 60 CS subjects receiving either 50,000 IU vitamin D supplements (n = 30) or placebo (n = 30) every 2 weeks for 24-weeks. Nicotine misuse, mental health scale, and metabolic parameters were measured before and after the intervention in the CS subjects. Compared with the placebo-group, after the 24-weeks intervention, serum 25 (OH) vitamin D levels increased in the intervention group (β 2.96; 95 CI, 0.91, 5.01; P = 0.006). In addition, vitamin D supplementation significantly improved Beck Depression Inventory (BDI) (β â��2.06; 95 CI, â��3.84, â��0.28; P = 0.02). In addition, vitamin D administration significantly decreased fasting plasma glucose (FPG) (β â��4.56; 95 CI, â��8.94, â��0.19; P = 0.04), insulin (β â��0.50; 95 CI, â��0.88, â��0.13; P = 0.009), and homeostasis model of assessment-estimated insulin resistance (HOMA-IR) levels (β â��0.21; 95 CI, â��0.33, â��0.08; P = 0.001). Furthermore, vitamin D resulted in a significant elevation in total antioxidant capacity (TAC) (β 81.20; 95 CI, 18.30, 144.11; P = 0.01), and plasma glutathione (GSH) levels (β 73.05; 95 CI, 18.56, 127.54; P = 0.01), compared with the placebo-group. Administration of vitamin D for 24-weeks to CS subjects had beneficial effects on symptoms of depression and several metabolic biomarkers. While this preliminary study suggests that vitamin D might have beneficial effects, its clinical efficacy in individuals with a tobacco use disorder should be further validated in future clinical trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Vitamin D supplementation,cigarette smokers,mental health,metabolic biomarkers,nicotine misuse |
| Subjects: | Pharmacology, Toxicology and Pharmaceutics |
| Depositing User: | editor . 5 |
| Date Deposited: | 08 Apr 2023 11:33 |
| Last Modified: | 08 Apr 2023 11:33 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/7756 |
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