Effect of calcium-vitamin D supplementation on metabolic profiles in pregnant women at risk for pre-eclampsia: A randomized placebo-controlled trial

Asemi, Z. and Tabassi, Z. and Heidarzadeh, Z. and Khorammian, H. and Sabihi, S.S. and Samimi, M. (2012) Effect of calcium-vitamin D supplementation on metabolic profiles in pregnant women at risk for pre-eclampsia: A randomized placebo-controlled trial. Pakistan Journal of Biological Sciences, 15 (7). pp. 316-324.

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Abstract

Increased metabolic profiles during pregnancy are associated with an increased risk of maternal and neonatal morbidity and remain a significant medical challenge. To our knowledge, no reports are available indicating the effects of calcium-vitamin D supplementation on metabolic profiles among pregnant women at risk for pre-eclampsia. This study was designed to determine the effects of consumption calcium-vitamin D supplements on metabolic profiles among Iranian pregnant women at risk for pre-eclampsia. This randomized single-blind controlled clinical trial was performed among 49 pregnant women at risk for pre-eclampsia, primigravida, aged 18-35 year old who were carrying singleton pregnancy at their third trimester. Subjects were randomly assigned to consume the placebo (n = 25) or calcium-vitamin D supplements (n = 24) for 9 weeks. Calcium-vitamin D supplements were containing 500 mg carbonate calcium plus 200 IU vitamin D3. Fasting blood samples were taken at baseline and after 9 week intervention to measures of Fasting Plasma Glucose (FPG) and serum lipid profiles. Consumption of calcium-vitamin D supplements resulted in decreased FPG and serum triglycerides levels as compared to the placebo (-9.1 vs. 0.5 mg dL-1; p = 0.03, -11.7 vs. 49.9 mg dL-1; p = 0.001, respectively). No significant differences were found comparing calcium-vitamin D supplements and the placebo in terms of their effect on serum total-, HDL-, LDL-cholesterol levels. Within-group differences in the placebo group revealed a significant increase in serum triglycerides levels (+49.9 mg dL-1, p<0.0001). In conclusion, consumption of calcium-vitamin D supplements for 9 weeks during pregnancy among pregnant women at risk for pre-eclampsia resulted in decreased FPG and serum triglycerides levels as compared to the placebo group, but could not affect serum total-, HDL-, LDL-cholesterol levels. © 2012 Asian Network for Scientific Information.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: biological marker; calcium carbonate; cholesterol; colecalciferol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol, adolescent; adult; article; blood; controlled clinical trial; controlled study; diet supplementation; drug combination; drug effect; female; glucose blood level; human; Iran; metabolism; preeclampsia; pregnancy; randomized controlled trial; risk factor; single blind procedure; third trimester pregnancy; time; treatment outcome, Adolescent; Adult; Biological Markers; Blood Glucose; Calcium Carbonate; Cholecalciferol; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dietary Supplements; Drug Combinations; Female; Humans; Iran; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Risk Factors; Single-Blind Method; Time Factors; Treatment Outcome; Triglycerides; Young Adult
Subjects: Nutrition
Divisions: Faculty of Medicine > Clinical Sciences > Department of , Obstetrics & Gynecology
Depositing User: editor . 2
Date Deposited: 01 Mar 2017 06:24
Last Modified: 01 Mar 2017 06:24
URI: http://eprints.kaums.ac.ir/id/eprint/763

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