A randomized controlled clinical trial investigating the effect of calcium supplement plus low-dose aspirin on hs-CRP, oxidative stress and insulin resistance in pregnant women at risk for pre-eclampsia

Asemi, Z. and Samimi, M. and Heidarzadeh, Z. and Khorrammian, H. and Tabassi, Z. (2012) A randomized controlled clinical trial investigating the effect of calcium supplement plus low-dose aspirin on hs-CRP, oxidative stress and insulin resistance in pregnant women at risk for pre-eclampsia. Pakistan Journal of Biological Sciences, 15 (10). pp. 469-476.

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Abstract

Increased levels of pro-inflammatory factors, markers of oxidative stress and insulin resistance during pregnancy have been associated with the development of pre-eclampsia. There is some evidence to suggest that calcium supplement and aspirin can reduce the risk of the disorder. To our knowledge, no reports are available indicating the effects of consumed calcium supplement plus aspirin on high sensitivity C-reactive protein (hs-CRP), oxidative stress parameters and insulin resistance in pregnant women at risk for pre-eclampsia. This study was designed to investigate the effects of consumed calcium supplement plus low-dose aspirin on hs-CRP, oxidative stress parameters and insulin resistance among Iranian pregnant women at risk for pre-eclampsia. This randomized single-blind controlled clinical trial was carried out among 42 pregnant women at risk for pre-eclampsia, primigravida, aged 18-40 year old who were carrying singleton pregnancy at their third trimester. Subjects were randomly assigned to received either the placebo (n = 22) or calcium supplement plus low-dose aspirin (n = 20) for 9 weeks. Calcium supplement plus low-dose aspirin were containing 500 mg carbonate calcium plus 80 mg aspirin. Fasting blood samples were taken at baseline and after 9 weeks intervention to measure serum hs-CRP, oxidative stress parameters including plasma Total Antioxidant Capacity (TAC) and Total Glutathione (GSH), Fasting Plasma Glucose (FPG), serum insulin and HOMA-IR score. Consumption of calcium supplement plus low-dose aspirin resulted in a significant difference serum hs-CRP levels as compared to the placebo (102.87 vs. 3227.75 ng mL-1, p = 0.01). Also, mean changes for plasma TAC (68.96 vs. -74.46 mmol L-1, p = 0.04) and total GSH levels (304.33 vs. -39.33 μmol L-1, p = 0.03) were significantly different between the two groups. No significant differences were found comparing calcium supplement plus low-dose aspirin and placebo in terms of their effects on FPG, serum insulin levels and HOMA-IR. Within-group differences in the placebo group revealed a significant increase in serum hs-CRP levels (3227.75 ng mL-1, p = 0.008) and marginally significant increase in plasma total GSH levels (304.33 μmol L-1, p = 0.07). In conclusion, consumption calcium supplement plus low-dose aspirin during pregnancy for 9 weeks in pregnant women at risk for pre-eclampsia resulted in a significant difference serum hs-CRP and increased levels of plasma TAC and total GSH as compared to the placebo group, but could not affect serum insulin levels and HOMA-IR score. © 2012 Asian Network for Scientific Information.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: acetylsalicylic acid; C reactive protein; calcium; glutathione; insulin, article; blood; controlled clinical trial; controlled study; diet supplementation; dose response; drug effect; female; glucose blood level; human; insulin resistance; Iran; metabolism; oxidative stress; preeclampsia; pregnancy; randomized controlled trial; risk factor, Aspirin; Blood Glucose; C-Reactive Protein; Calcium; Dietary Supplements; Dose-Response Relationship, Drug; Female; Glutathione; Humans; Insulin; Insulin Resistance; Iran; Oxidative Stress; Pre-Eclampsia; Pregnancy; Risk Factors
Subjects: Medicine
Nutrition
Divisions: Faculty of Medicine > Clinical Sciences > Department of , Obstetrics & Gynecology
Depositing User: editor . 2
Date Deposited: 01 Mar 2017 06:34
Last Modified: 01 Mar 2017 06:34
URI: http://eprints.kaums.ac.ir/id/eprint/744

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