Serum parameters predict the severity of ultrasonographic findings in non-alcoholic fatty liver disease

Razavizadeh, M. and Jamali, R. and Arj, A. and Talari, H. (2012) Serum parameters predict the severity of ultrasonographic findings in non-alcoholic fatty liver disease. Hepatobiliary and Pancreatic Diseases International, 11 (5). pp. 513-520.

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Background: Controversy exists about the correlation between liver ultrasonography and serum parameters for evaluating the severity of liver involvement in non-alcoholic fatty liver disease (NAFLD). This study was designed to determine the association between liver ultrasonography staging in NAFLD and serum parameters correlated with disease severity in previous studies; and set optimal cutoff points for those serum parameters correlated with NAFLD staging at ultrasonography, in order to differentiate ultrasonographic groups (USGs). Methods: This cross-sectional study evaluated outpatients with evidence of NAFLD in ultrasonography referred to a general hospital. Those with positive viral markers, abnormal serum ceruloplasmin or gamma-globulin concentrations were excluded. A radiologist performed the ultrasonography staging and stratified the patients into mild, moderate, and severe groups. Fasting serum alanine aminotransferase (ALT), aspartate aminotransferase, alkaline phosphatase, triglyceride (TG), high and low density lipoprotein (HDL, LDL), and cholesterol were checked. Results: Two hundred and forty-five patients with a mean age (±standard deviation) of 41.63(±11.46) years were included. There were no significant differences when mean laboratory concentrations were compared between moderate and severe USGs. Therefore, these groups were combined to create revised USGs ("mild" versus "moderate or severe"). There were associations between the revised USGs, and ALT, TG, HDL levels, and diabetes mellitus odds ratios=2.81 (95% confidence interval (CI): 1.37-5.76), 2.48 (95% CI: 1.29-4.78), 0.36 (95% CI: 0.18-0.74), and 5.65 (95% CI: 2.86-11.16) respectively; all P values <0.01. A cut-off value of 32.5 mg/dL for ALT gave a sensitivity of 70% and a specificity of 62%, for differentiating between the revised USGs. Conclusions: Serum ALT, TG, and HDL concentrations seem to be associated with the staging by liver ultrasonography in NAFLD. They might be used to predict the staging of liver ultrasonography in these patients. © 2012, Hepatobiliary Pancreat Dis Int.

Item Type: Article
Additional Information: cited By 19
Uncontrolled Keywords: alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; biological marker; ceruloplasmin; high density lipoprotein cholesterol; immunoglobulin; low density lipoprotein cholesterol; triacylglycerol, adult; alanine aminotransferase blood level; alkaline phosphatase blood level; article; aspartate aminotransferase blood level; cross-sectional study; disease severity; echography; female; human; major clinical study; male; nonalcoholic fatty liver; prediction; radiologist; triacylglycerol blood level, Adolescent; Adult; Aged; Alanine Transaminase; Biological Markers; Cholesterol, HDL; Cross-Sectional Studies; Fatty Liver; Female; Humans; Male; Middle Aged; Severity of Illness Index; Triglycerides
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Internal Medicine
Depositing User: editor . 2
Date Deposited: 01 Mar 2017 06:33
Last Modified: 11 Mar 2017 17:02

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