The evaluation of increase in hemodialysis frequency on C-reactive protein levels and nutritional status

Rashidi, A.A. and Soleimani, A.R. and Nikoueinejad, H. and Sarbolouki, S. (2013) The evaluation of increase in hemodialysis frequency on C-reactive protein levels and nutritional status. Acta Medica Iranica, 51 (2). pp. 119-124.

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Malnutrition and inflammation are the most important causes of cardiovascular disease in hemodialysis patients. This study was conducted to evaluate the effect of increase in hemodialysis frequency on C-reactive protein (CRP) level and nutritional markers in contrast to previous routine method. 18 hemodialysis patients with a mean age of 53±16 years were randomly selected in this before-and-after clinical trial. The patients under a standard hemodialysis of 3 times/4 h per week were converted to 4 times/4 h for a period of 6 weeks. The CRP, albumin, triglyceride, total cholesterol, LDL, HDL serum levels, anthropometric indices and 24-h diet recall intake was assessed before and after of the period. The data were analyzed using paired t-test, and P-value less than 0.05 was considered significant. All patients completed the study. Mean weight, body mass index and serum albumin increased while serum CRP level decreased significantly after the intervention (P<0.03). Triglyceride, total cholesterol, LDL, HDL, as well as energy, protein and fat intake had no significant change before and after the study. Increase in dialysis frequency decreased systemic inflammation and improved the nutritional state of hemodialysis patients. Therefore, it may decrease the risk of cardiovascular events in these patients. © 2013 Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: albumin; C reactive protein; cholesterol; high density lipoprotein; low density lipoprotein; triacylglycerol; ALB protein, human; autacoid; biological marker; C reactive protein; lipid; serum albumin, adult; article; body mass; body weight; clinical article; dietary intake; female; hemodialysis; human; immunonephlometry; inflammation; male; middle aged; nephelometry; nutritional status; randomized controlled trial (topic); aged; blood; cardiovascular disease; chronic kidney failure; clinical trial; immunology; inflammation; malnutrition; metabolism; methodology; nutritional assessment; pathophysiology; renal replacement therapy; time; treatment outcome, Adult; Aged; Biological Markers; C-Reactive Protein; Cardiovascular Diseases; Female; Humans; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Lipids; Male; Malnutrition; Middle Aged; Nutrition Assessment; Nutritional Status; Renal Dialysis; Serum Albumin; Time Factors; Treatment Outcome
Subjects: Medicine
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 03 Mar 2017 12:45
Last Modified: 03 Mar 2017 12:45

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