A comparison of rectal misoprostol and intravenous oxytocin on hemorrhage and homeostatic changes during cesarean section

Fazel, M.R. and Samimi, M. and Fakharian, E. (2013) A comparison of rectal misoprostol and intravenous oxytocin on hemorrhage and homeostatic changes during cesarean section. Middle East Journal of Anesthesiology, 22 (1). pp. 41-46.

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DOI: UNSPECIFIED

Abstract

Background: Post partum bleeding is a major cause of mortality and morbidity in pregnant women. In this study the effects of rectal misoprostol and oxytocin on post-cesarean bleeding are compared. Methods: In this clinical trial 100 pregnant women candidate of elective cesarean section (CS) were randomly allocated in one of two groups of patients receiving either 400 μg of misoprostol, rectally, after spinal anesthesia, or intravenous oxytocin, after delivery of the baby. Intra-operative bleeding, hemoglobin level before and 24 hour after operation, mean arterial blood pressure, heart rate before and after the administration of the drugs, and adverse drug effects. Results: There was no difference between the groups in age, duration and number of pregnancy, and surgery. The amount of the blood lost in misoprostol group was 578±185 cc, and in oxytocin group 620±213 cc (p=0.39). Decrease in hemoglobin level in the two groups was not statistically significant (p=0.55). Changes in mean arterial pressure and heart rate were only significant in oxytocin group. Shivering was significantly more common in the misoprostol group and respiratory distress in the oxytocin group. Other adverse effects were equally seen in both groups. Conclusion: Misoprostol is an appropriate alternative for intravenous oxytocin in patients undergoing cesarean section, with lesser side effects and longer duration of action. Financial support: Kashan University of Medical Sciences, Faculty of Medicine, Deputy of Research. Conflict of interest: The authors have no conflict of interest.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: hemoglobin; misoprostol; oxytocin, adult; article; blood pressure; cesarean section; comparative study; controlled clinical trial; controlled study; drug effect; female; heart rate; human; intravenous drug administration; postpartum hemorrhage; pregnancy; randomized controlled trial; rectal drug administration, Administration, Rectal; Adult; Blood Pressure; Cesarean Section; Female; Heart Rate; Hemoglobins; Humans; Infusions, Intravenous; Misoprostol; Oxytocin; Postpartum Hemorrhage; Pregnancy
Subjects: Surgery
Divisions: Faculty of Medicine > Clinical Sciences > Department of Special Surgery
Depositing User: editor . 2
Date Deposited: 03 Mar 2017 13:27
Last Modified: 03 Mar 2017 13:27
URI: http://eprints.kaums.ac.ir/id/eprint/685

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