Erythropoietin improves spatial learning and memory in streptozotocin model of dementia

Hamidi, G.A. and Arabpour, Z. and Shabrang, M. and Rashidi, B. and Alaei, H. and Sharifi, M.R. and Salami, M. and Reisi, P. (2013) Erythropoietin improves spatial learning and memory in streptozotocin model of dementia. Pathophysiology, 20 (2). pp. 153-158.

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Abstract

Alzheimer's disease is associated to impairments of learning and memory. Because studies demonstrated that erythropoietin has positive effects on central nervous system, the aim of this study was to evaluate the effect of erythropoietin on spatial learning and memory in a well defined model for Alzheimer's disease. Rat model of Alzheimer's was created by injecting streptozotocin in lateral ventricles of the brain. Two weeks later, the rats were assessed through passive avoidance learning test to confirm the induction of Alzheimer's. After that, they received erythropoietin (5000. IU/kg) every other day, for two weeks and then spatial learning and memory were assessed by a 5-day protocol of Morris water maze test in them. The results showed that streptozotocin severely damaged learning and memory in rats. Erythropoietin had no significant effect in the control rats; however, it significantly improved learning and memory in rats with Alzheimer's disease, as the task performance of the rats treated with erythropoietin was like the control group. The results suggest that erythropoietin can be considered as an effective treatment for neurodegenerative damages. © 2013 Elsevier Ireland Ltd.

Item Type: Article
Additional Information: cited By 7
Uncontrolled Keywords: erythropoietin; streptozocin, Alzheimer disease; animal experiment; animal model; article; controlled study; dementia; latent period; male; maze test; memory disorder; neuroprotection; nonhuman; passive avoidance; priority journal; rat; spatial learning; spatial memory
Subjects: Physiology
Divisions: Faculty of Medicine > Basic Sciences > Department of physiology
Depositing User: editor . 2
Date Deposited: 03 Mar 2017 13:32
Last Modified: 03 Mar 2017 13:32
URI: http://eprints.kaums.ac.ir/id/eprint/671

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