Jafari-Sabet, M. and Banafshe, H.R. and Khodadadnejad, M.A. (2013) Modulation of muscimol state-dependent memory by alpha 2- adrenoceptors of the dorsal hippocampal area. European Journal of Pharmacology, 710 (1-3). pp. 92-99.
Full text not available from this repository.Abstract
In the present study, the effects of bilateral intra-dorsal hippocampal (intra-CA1) injections of α2-adrenoceptor agonist and antagonist, on muscimol state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Administration of muscimol (0.1 μg/mouse, intra-CA1) 15 min before training or testing induced impairment of memory retention. Injection of the same dose of the drug 15 min before testing restored memory retention impaired under pre-training muscimol influence. Pre-test intra-CA1 administration of the α2-adrenoceptor agonist clonidine (0.5 and 1 μg/mouse) impaired memory retention, although the low dose of the drug (0.25 μg/mouse) did not affect memory retention. Pre-test intra-CA1 administration of the α2-adrenoceptor antagonist yohimbine (1 and 2 μg/mouse) improved memory retention, although the low dose of the drug (0.5 μg/mouse) did not affect memory retention. In other series of experiments, pre-test co-administration of certain doses of clonidine (0.125 and 0.25 μg/mouse, intra-CA1), doses which were ineffective when given alone, and muscimol (0.1 μg/mouse, intra-CA1) significantly inhibited muscimol state-dependent memory. Pre-test intra-CA1 administration of certain doses of yohimbine (0.25 and 0.5 μg/mouse), doses which were ineffective when given alone, improved pre-training muscimol (0.1 μg/mouse)-induced retrieval impairment. Moreover, pre-test co-administration of yohimbine (0.25 and 0.5 μg/mouse, intra-CA1) and muscimol (0.025 μg/mouse, intra-CA1), an ineffective dose, significantly restored the retrieval and induced muscimol state-dependent memory. It may be concluded that the α2-adrenoceptors of the dorsal hippocampal area play an important role in muscimol state-dependent memory. © 2013 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 5 |
| Uncontrolled Keywords: | 4 aminobutyric acid A receptor; alpha 2 adrenergic receptor; clonidine; muscimol; yohimbine, animal experiment; article; controlled study; hippocampus; male; memory; memory consolidation; mouse; nonhuman; passive avoidance; priority journal; recall; state dependent memory, Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Avoidance Learning; CA1 Region, Hippocampal; Clonidine; GABA-A Receptor Agonists; Male; Memory Disorders; Mice; Muscimol; Receptors, Adrenergic, alpha-2; Yohimbine |
| Subjects: | Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Faculty of Medicine > Basic Sciences > Department of Pharmacology |
| Depositing User: | editor . 2 |
| Date Deposited: | 03 Mar 2017 14:44 |
| Last Modified: | 03 Mar 2017 14:44 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/641 |
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