Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women

Asemi, Z. and Samimi, M. and Tabassi, Z. and Shakeri, H. and Esmaillzadeh, A. (2013) Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. Journal of Nutrition, 143 (9). pp. 1432-1438.

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Abstract

Unfavorable metabolic profiles and oxidative stress in pregnancy are associated with several complications. This study was conducted to determine the effects of vitamin D supplementation on serum concentrations of high-sensitivity C-reactive protein (hs-CRP), metabolic profiles, and biomarkers of oxidative stress in healthy pregnant women. This randomized, double-blind, placebo-controlled clinical trial was conducted in 48 pregnant women aged 18-40 y old at 25 wk of gestation. Participants were randomly assigned to receive either 400 IU/d cholecalciferol supplements (n = 24) or placebo (n = 24) for 9 wk. Fasting blood samples were taken at study baseline and after 9 wk of intervention to quantify serum concentrations of hs-CRP, lipid concentrations, insulin, and biomarkers of oxidative stress. After 9 wk of intervention, the increases in serum 25-hydroxyvitamin D and calcium concentrations were greater in the vitamin D group (+3.7 μg/L and +0.20 mg/dL, respectively) than in the placebo group (-1.2 μg/L and 20.12 mg/dL, respectively; P < 0.001 for both). Vitamin D supplementation resulted in a significant decrease in serum hs-CRP (vitamin D vs. placebo groups: -1.41 vs. +1.50 μg/mL; P-interaction = 0.01) and insulin concentrations (vitamin D vs. placebo groups: -1.0 vs. +2.6 μIU/mL; P-interaction = 0.04) and a significant increase in the Quantitative Insulin Sensitivity Check Index score (vitamin D vs. placebo groups: +0.02 vs. -0.02; P-interaction = 0.006), plasma total antioxidant capacity (vitamin D vs. placebo groups: +152 vs. -20 mmol/L; P-interaction = 0.002), and total glutathione concentrations (vitamin D vs. placebo groups: +205 vs. -32 μmol/L; Pinteraction = 0.02) compared with placebo. Intake of vitamin D supplements led to a significant decrease in fasting plasma glucose (vitamin D vs. placebo groups: -0.65 vs.20.12mmol/L; P-interaction = 0.01), systolic blood pressure (vitamin D vs. placebo groups: -0.2 vs. +5.5 mm Hg; P-interaction = 0.01), and diastolic blood pressure (vitamin D vs. placebo groups: -0.4 vs. +3.1 mm Hg; P-interaction = 0.01) compared with placebo. In conclusion, vitamin D supplementation for 9 wk among pregnant women has beneficial effects on metabolic status. © 2013 American Society for Nutrition.

Item Type: Article
Additional Information: cited By 43
Uncontrolled Keywords: 25 hydroxyvitamin D; antioxidant; biological marker; C reactive protein; calcium; colecalciferol; glucose; glutathione; insulin; lipid; placebo; vitamin D, adult; article; calcium blood level; clinical article; controlled clinical trial; controlled study; diastolic blood pressure; disease association; double blind procedure; drug effect; female; glucose blood level; human; insulin resistance; lipid blood level; metabolic parameters; oxidative stress; pregnancy; pregnant woman; protein blood level; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; sensitivity analysis; systolic blood pressure; treatment duration; vitamin blood level; vitamin intake; vitamin supplementation, Adolescent; Adult; Antioxidants; Biological Markers; Blood Glucose; C-Reactive Protein; Dietary Supplements; Double-Blind Method; Fasting; Female; Glutathione; Humans; Insulin; Insulin Resistance; Oxidative Stress; Pregnancy; Vitamin D; Young Adult
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 03 Mar 2017 16:03
Last Modified: 03 Mar 2017 16:03
URI: http://eprints.kaums.ac.ir/id/eprint/625

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