Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes

Asemi, Z. and Zare, Z. and Shakeri, H. and Sabihi, S.S. and Esmaillzadeh, A. (2013) Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes. Annals of Nutrition and Metabolism, 63 (1-2). pp. 1-9.

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Abstract

Background: We are aware of no study that has indicated the effects of daily consumption of multispecies probiotic supplements on metabolic profiles, high-sensitivity C-reactive protein (hs-CRP), and oxidative stress in diabetic patients. Objective: This study was designed to determine the effects of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in diabetic patients. Methods: This randomized double-blind placebo-controlled clinical trial was performed on 54 diabetic patients aged 35-70 years. Subjects were randomly assigned to take either a multispecies probiotic supplement (n = 27) or placebo (n = 27) for 8 weeks. The multispecies probiotic supplement consisted of 7 viable and freeze-dried strains: Lactobacillus acidophilus (2 � 109 CFU), L. casei (7 � 109 CFU), L. rhamnosus (1.5 � 109 CFU), L. bulgaricus (2 � 108 CFU), Bifidobacterium breve (2 � 1010 CFU), B. longum (7 � 109 CFU), Streptococcus thermophilus (1.5 � 109 CFU), and 100 mg fructo- oligosaccharide. Fasting blood samples were taken at baseline and after intervention to measure metabolic profiles, hs-CRP, and biomarkers of oxidative stress including plasma total antioxidant capacity and total glutathione (GSH). Results: Between-group comparisons of fasting plasma glucose (FPG) revealed that consumption of probiotic supplements prevented a rise in FPG (+28.8 ± 8.5 for placebo vs. +1.6 ± 6 mg/dl for probiotic group, p = 0.01). Although a significant within-group increase in serum insulin and low-density lipoprotein cholesterol levels was found in both the probiotic group and the placebo group, the changes were similar between the two groups. We observed a significant increase in HOMA-IR (homeostasis model of assessment-insulin resistance) in both the probiotic group (p = 0.02) and the placebo group (p = 0.001); however, the increase in the placebo group was significantly higher than that in the probiotic group (+2.38 vs. +0.78, p = 0.03). Mean changes in serum hs-CRP were significantly different between the two groups (-777.57 for the probiotic group vs. +878.72 ng/ml for the placebo group, p = 0.02). Probiotic supplementation led to a significant increase in plasma GSH levels compared to placebo (240.63 vs. -33.46 μmol/l, p = 0.03). Conclusion: In conclusion, multispecies probiotic supplementation, compared with placebo, for 8 weeks in diabetic patients prevented a rise in FPG and resulted in a decrease in serum hs-CRP and an increase in plasma total GSH. Copyright © 2013 S. Karger AG, Basel.

Item Type: Article
Additional Information: cited By 38
Uncontrolled Keywords: C reactive protein; fructose oligosaccharide; glutathione; insulin; low density lipoprotein cholesterol; placebo; probiotic agent; cholesterol; glucose; hemoglobin A1c; high density lipoprotein cholesterol; probiotic agent; triacylglycerol; uric acid, adult; aged; article; Bifidobacterium breve; Bifidobacterium longum; blood sampling; controlled study; double blind procedure; human; insulin blood level; insulin resistance; Lactobacillus acidophilus; Lactobacillus bulgaricus; Lactobacillus casei; Lactobacillus rhamnosus; major clinical study; non insulin dependent diabetes mellitus; oxidative stress; priority journal; randomized controlled trial; Streptococcus thermophilus; analytical parameters; Article; cholesterol blood level; diabetic patient; female; glucose blood level; hemoglobin blood level; Lactobacillus delbrueckii subsp. bulgaricus; male; metabolism; total antioxidant capacity; triacylglycerol blood level, Bifidobacterium breve; Lactobacillus acidophilus; Streptococcus thermophilus; Bifidobacterium breve; Lactobacillus acidophilus; Streptococcus thermophilus, Adult; Aged; Antioxidants; Bifidobacterium; Biological Markers; Blood Glucose; Body Mass Index; Body Weight; C-Reactive Protein; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; Energy Intake; Freeze Drying; Glutathione; Humans; Insulin Resistance; Lactobacillus acidophilus; Metabolome; Middle Aged; Oxidative Stress; Probiotics; Streptococcus thermophilus
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 03 Mar 2017 15:49
Last Modified: 12 Mar 2017 14:38
URI: http://eprints.kaums.ac.ir/id/eprint/617

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