Ghaderi, A. and Banafshe, H. and Aghadavod, E. and Gholami, M. and Asemi, Z. and Mesdaghinia, A. (2020) The effects of Vitamin D supplementation on withdrawal symptoms and the expression of inflammatory cytokines and insulin in patients under methadone maintenance treatment: A randomized, double-blind, placebo-controlled trial. Iranian Journal of Psychiatry and Behavioral Sciences, 14 (1).
|
Text
The_Effects_of_Vitamin_D_Supplementation_on_Withdr.pdf Download (165kB) | Preview |
Abstract
Background: Hypovitaminosis D may be related to some metabolic vulnerable, including metabolic disorders associated with inflammatory cytokines and insulin resistance in subjects undergoing methadone maintenance treatment (MMT). Objectives: This study aimed to determine the impact of vitamin D intake on withdrawal symptoms and genetic response related to inflammatory cytokines and insulin in patients treated with MMT. Methods: This investigation was performed on 40 subjects under MMT to consume either 50,000 IU vitamin D supplements (n = 20) or placebo (n = 20) every 2 weeks for 12 weeks, between April and June 2017 in Kashan, Iran. The clinical opiate withdrawal symptoms (COWS) were evaluated to examine withdrawal scale and gene expression at baseline and after the a 3-month intervention. Statistical analysis of the data was performed using SPSS 18 with Fisher's exact test, t-test, chi-square, and ANCOVA. Also, P values < 0.05 were considered statistically significant. Results: The results of our study showed that compared with the placebo, taking vitamin D downregulated interleukin-1 (IL-1) expression (P = 0.01) in peripheral blood mononuclear cells (PBMCs) of patients under MMT. In addition, consuming vitamin D increased peroxisome proliferator-activated receptor gamma (PPAR-γ) expression (P = 0.01). Administration of vitamin D did not change COWS and IL-8 and tumor necrosis factor-alpha (TNF-α) expression. Conclusions: According to the results of the present study, vitamin D can be recommended as an adjunct to MMT which may elevate the quality of life and decrease methadone side effects. Copyright © 2020, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | benzodiazepine derivative; colecalciferol; cytokine; insulin; interleukin 1; interleukin 8; methadone; opiate; peroxisome proliferator activated receptor gamma; tumor necrosis factor, adult; Article; clinical article; controlled study; double blind procedure; down regulation; gene expression; human; insulin metabolism; Iran; male; methadone treatment; opiate addiction; peripheral blood mononuclear cell; protein expression; randomized controlled trial; real time polymerase chain reaction; upregulation; vitamin supplementation; withdrawal syndrome |
| Subjects: | Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Faculty of Medicine > Basic Sciences > Addiction Studies |
| Depositing User: | ART . editor |
| Date Deposited: | 19 Oct 2020 10:29 |
| Last Modified: | 19 Oct 2020 10:29 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/5455 |
Actions (login required)
 |
View Item |
