Can melatonin help us in radiation oncology treatments?

Mihandoost, E. and Shirazi, A. and Mahdavi, S.R. and Aliasgharzadeh, A. (2014) Can melatonin help us in radiation oncology treatments? BioMed Research International, 2014.

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Abstract

Nowadays, radiotherapy has become an integral part of the treatment regimen in various malignancies for curative or palliative purposes. Ionizing radiation interacts with biological systems to produce free radicals, which attack various cellular components. Radioprotectors act as prophylactic agents that are administered to shield normal cells and tissues from the harmful effects of radiation. Melatonin has been shown to be both a direct free radical scavenger and an indirect antioxidant by stimulating antioxidant enzymes and suppressing prooxidative enzymes activity. In addition to its antioxidant property, there have also been reports implicating antiapoptotic function for melatonin in normal cells. Furthermore, through its antitumor and radiosensitizing properties, treatment with melatonin may prevent tumor progression. Therefore, addition of melatonin to radiation therapy could lower the damage inflicted to the normal tissue, leading to a more efficient tumor control by use of higher doses of irradiation during radiotherapy. Thus, it seems that, in the future, melatonin may improve the therapeutic gain in radiation oncology treatments. © 2014 Ehsan Mihandoost et al.

Item Type: Article
Additional Information: cited By 5
Uncontrolled Keywords: alpha tocopherol; amifostine; antioxidant; free radical; glutathione; malonaldehyde; melatonin; protein p21; protein p53; radioprotective agent; superoxide dismutase; antioxidant; melatonin; radioprotective agent; scavenger, antineoplastic activity; antioxidant activity; apoptosis; cancer inhibition; cancer palliative therapy; cancer radiotherapy; dose time effect relation; drug synthesis; enzyme activation; hormone synthesis; human; nonhuman; radiation dose; radiation injury; radiation protection; radiosensitization; review; tumor growth; animal; drug effects; oncology; procedures, Animals; Antioxidants; Apoptosis; Free Radical Scavengers; Humans; Melatonin; Radiation Oncology; Radiation-Protective Agents
Subjects: Health Professions
Divisions: Faculty of Para medicine > Department of Management Radiology and Medical Physics
Depositing User: editor . 2
Date Deposited: 04 Mar 2017 07:01
Last Modified: 04 Mar 2017 07:01
URI: http://eprints.kaums.ac.ir/id/eprint/541

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