Effects of omega-3 fatty acid plus alpha-tocopherol supplementation on malnutrition inflammation score, biomarkers of inflammation and oxidative stress in chronic hemodialysis patients

Asemi, Z. and Soleimani, A. and Shakeri, H. and Mazroii, N. and Esmaillzadeh, A. (2016) Effects of omega-3 fatty acid plus alpha-tocopherol supplementation on malnutrition inflammation score, biomarkers of inflammation and oxidative stress in chronic hemodialysis patients. International Urology and Nephrology, 48 (11). pp. 1887-1895.

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Abstract

Objective: The current study was carried out to assess the effects of omega-3 fatty acid and alpha-tocopherol co-supplementation on malnutrition�inflammation score (MIS), biomarkers of inflammation and oxidative stress in chronic hemodialysis (HD) patients. Methods: In a randomized double-blind placebo-controlled clinical trial, 120 patients with chronic HD� were included. Patients were randomly allocated into four groups to receive: (1) 1250� mg/day omega-3 fatty acid containing 600� mg EPA and 300� mg DHA� +� alpha-tocopherol placebo (n� =� 30); (2) 400� IU/day alpha-tocopherol� +� omega-3 fatty acids placebo (n� =� 30); (3) 1250� mg omega-3 fatty acids/day� +� 400� IU/day alpha-tocopherol (n� =� 30); and (4) omega-3 fatty acids placebo� +� alpha-tocopherol placebo (n� =� 30) for 12� weeks. Results: After 12� weeks of intervention, all three groups of alpha-tocopherol only, individual omega-3 fatty acids, and combined omega-3 fatty acids and alpha-tocopherol experienced a significant improvements in MIS compared with the placebo group; however, improvements were much greater in the individual omega-3 fats (�1.4� �±� 1.4) and combined omega-3 fats and alpha-tocopherol (�1.1� �±� 2.3) groups compared with alpha-tocopherol group alone (�0.5� �±� 1.7, P� =� 0.004). Furthermore, both individual and combined intervention with omega-3 fats and alpha-tocopherol led to a significant increase in plasma nitric oxide (NO) (combined group: +17.6� �±� 29.3; alpha-tocopherol: +43.1� �±� 36.3; omega-3 fats: +31.0� �±� 40.0; and placebo: �0.5� �±� 18.5� �µmol/L, respectively, P� <� 0.001) and total antioxidant capacity (TAC) (+64.9� �±� 113.6, +53.0� �±� 144.6, +57.6� �±� 157.8 and �69.9� �±� 215.1� mmol/L, respectively, P� =� 0.004) levels. Conclusion: Overall, omega-3 fatty acids and alpha-tocopherol co-supplementation for 12� weeks among HD patients improved MIS, plasma NO and TAC levels. Future studies with longer duration of the intervention are needed to confirm the validity of our findings. Clinical registration: www.irct.ir as IRCT201410245623N28. �© 2016, Springer Science+Business Media Dordrecht.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: alpha tocopherol; biological marker; docosahexaenoic acid; icosapentaenoic acid; nitric oxide; omega 3 fatty acid; placebo, adult; aged; antioxidant activity; Article; blood level; combination chemotherapy; controlled study; double blind procedure; drug efficacy; female; hemodialysis patient; human; inflammation; major clinical study; male; malnutrition; medication compliance; monotherapy; oxidative stress; patient compliance; randomized controlled trial; scoring system; supplementation
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 03 Mar 2017 17:51
Last Modified: 03 Mar 2017 17:51
URI: http://eprints.kaums.ac.ir/id/eprint/54

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