Consequences of lethal-whole-body gamma radiation and possible ameliorative role of melatonin

Mihandoost, E. and Shirazi, A. and Mahdavi, S.R. and Aliasgharzadeh, A. (2014) Consequences of lethal-whole-body gamma radiation and possible ameliorative role of melatonin. Scientific World Journal, 2014.

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DOI: UNSPECIFIED

Abstract

Gamma radiation induces the generation of free radicals, leading to serious cellular damages in biological systems. Radioprotectors act as prophylactic agents that are administered to shield normal cells and tissues from the deleterious effects of radiation. Melatonin synergistically acts as an immune-stimulator and antioxidant. We investigated the possible radioprotective role of melatonin (100 mg/kg i.p.) against lethal-whole-body radiation- (10 Gy) induced sickness, body weight loss, and mortality in rats. Results of the present study suggest that exposure to lethal-whole-body radiation incurred mortality, body weight loss, and apoptosis and it also depleted the immunity and the antioxidant status of the rats. Our results show that melatonin pretreatment provides protection against radiation induced mortality, oxidative stress, and immune-suppression. The melatonin pretreated irradiated rats showed less change in body weight as compared to radiation only group. On the other hand, melatonin appeared to have another radioprotective role, suggesting that melatonin may reduce apoptosis through a caspase-3-mediated pathway by blocking caspase-3 activity. © 2014 Ehsan Mihandoost et al.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: caspase 3; catalase; glutathione peroxidase; malonaldehyde; melatonin; superoxide dismutase; antioxidant; caspase 3; catalase; glutathione peroxidase; melatonin; radioprotective agent; superoxide dismutase, adult; animal experiment; animal model; animal tissue; antioxidant activity; apoptosis; Article; controlled study; enzyme inhibition; gamma radiation; immune deficiency; lipid peroxidation; lymphocyte count; male; mortality; nonhuman; oxidative stress; radiation exposure; radiation protection; rat; weight reduction; whole body radiation; adverse effects; animal; body weight; gamma radiation; gene expression; genetics; immunology; innate immunity; lymphocyte; metabolism; pathology; Radiation Injuries; radiation response; survival; whole body radiation; Wistar rat, Rattus, Animals; Antioxidants; Apoptosis; Body Weight; Caspase 3; Catalase; Gamma Rays; Gene Expression; Glutathione Peroxidase; Immunity, Innate; Lymphocytes; Male; Melatonin; Oxidative Stress; Radiation Injuries; Radiation-Protective Agents; Rats; Rats, Wistar; Superoxide Dismutase; Survival Analysis; Whole-Body Irradiation
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Para medicine > Department of Management Radiology and Medical Physics
Depositing User: editor . 2
Date Deposited: 04 Mar 2017 06:59
Last Modified: 04 Mar 2017 06:59
URI: http://eprints.kaums.ac.ir/id/eprint/538

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