Effects of daily consumption of synbiotic bread on insulin metabolism and serum high-sensitivity c-reactive protein among diabetic patients: A double-blind, randomized, controlled clinical trial

Tajabadi-Ebrahimi, M. and Bahmani, F. and Shakeri, H. and Hadaegh, H. and Hajijafari, M. and Abedi, F. and Asemi, Z. (2014) Effects of daily consumption of synbiotic bread on insulin metabolism and serum high-sensitivity c-reactive protein among diabetic patients: A double-blind, randomized, controlled clinical trial. Annals of Nutrition and Metabolism, 65 (1). pp. 34-41.

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Abstract

Background: This study was conducted to evaluate the effects of daily consumption of synbiotic bread on the metabolic status of patients with type 2 diabetes mellitus. Methods: This randomized, double-blind, controlled clinical trial was performed in 81 diabetic patients. The subjects were randomly assigned to consumption of synbiotic (n = 27), probiotic (n = 27), or control bread (n = 27) for 8 weeks 3 times a day in a 40-gram package. The synbiotic bread contained Lactobacillus sporogenes (1�10 8 CFU) and 0.07 g inulin per 1 g. The probiotic bread contained L. sporogenes (1 � 10 8 CFU per 1 g). Fasting blood samples were taken at baseline and after an 8-week intervention for quantification of related factors. Results: Consumption of the synbiotic bread resulted in a significant reduction in serum insulin levels (-3.2 ± 5.4 vs. -0.3 ± 3.4 and 0.6 ± 4.7 μIU/ml, respectively, p = 0.007), homeostatic model assessment for insulin resistance scores (-1.5 ± 2.7 vs. -0.2 ± 1.6 and 0.4 ± 3.5, respectively, p = 0.03), and homeostatic model assessment-β-cell function (-7.2 ± 16.3 vs. -0.7 ± 10.8 and 0.7 ± 8.2, respectively, p = 0.04) compared to the probiotic and control breads. We did not find any significant effect of synbiotic bread consumption on fasting plasma glucose, the quantitative insulin sensitivity check index, or serum hs-CRP levels compared to other breads. Conclusion: Consumption of the synbiotic bread among diabetic patients had beneficial effects on insulin metabolism. © 2014 S. Karger AG, Basel.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: C reactive protein; probiotic agent; synbiotic agent; C reactive protein; glucose blood level; insulin; probiotic agent; synbiotic agent, adult; Article; blood sampling; bread; cell function; controlled study; diabetic patient; double blind procedure; female; food intake; homeostasis; human; insulin blood level; insulin metabolism; Lactobacillus; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; protein blood level; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; analysis; blood; bread; Diabetes Mellitus, Type 2; glucose blood level; insulin resistance; Iran; metabolism; microbiology, Blood Glucose; Bread; C-Reactive Protein; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Insulin; Insulin Resistance; Iran; Lactobacillus; Male; Middle Aged; Probiotics; Synbiotics
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 04 Mar 2017 07:20
Last Modified: 11 Mar 2017 16:25
URI: http://eprints.kaums.ac.ir/id/eprint/526

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