Consumption of synbiotic bread decreases triacylglycerol and VLDL levels while increasing HDL levels in serum from patients with type-2 diabetes

Shakeri, H. and Hadaegh, H. and Abedi, F. and Tajabadi-Ebrahimi, M. and Mazroii, N. and Ghandi, Y. and Asemi, Z. (2014) Consumption of synbiotic bread decreases triacylglycerol and VLDL levels while increasing HDL levels in serum from patients with type-2 diabetes. Lipids, 49 (7). pp. 695-701.

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To our knowledge, no reports are available indicating the favorable effects of synbiotic bread consumption on blood lipid profiles among patients with type 2 diabetes mellitus (T2DM). This study was conducted to evaluate the effects of the daily consumption of synbiotic bread on blood lipid profiles of patients with T2DM. This randomized double-blinded controlled clinical trial was performed with 78 diabetic patients, aged 35-70 years. After a 2-week run-in period, subjects were randomly assigned to consume either synbiotic (n = 26), probiotic (n = 26) or control bread (n = 26) for 8 weeks. The synbiotic bread contained viable and heat-resistant probiotic Lactobacillus sporogenes (1 � 108 CFU) and 0.07 g inulin (HPX) as prebiotic per 1 g. The probiotic bread contained L. sporogenes (1 � 108 CFU) per 1 g. Patients were asked to consume the synbiotic, probiotic and control breads three times a day in a 40 g package for a total of 120 g/day. Biochemical measurements including blood lipid profiles were conducted before and after 8 weeks of intervention. Consumption of the synbiotic bread, compared to the probiotic and control breads, led to a significant decrease in serum TAG (P = 0.005), VLDL-C (P = 0.005), TC/HDL-C (P = 0.002) and a significant increase in serum HDL-C levels (P = 0.01). No significant effect of synbiotic bread consumption on FPG, TC, LDL-C and non-HDL-C levels was seen compared to the probiotic and control breads (P > 0.05). Trial registry code: IRCT201311215623N13. © 2014 AOCS.

Item Type: Article
Additional Information: cited By 12
Uncontrolled Keywords: high density lipoprotein; inulin; probiotic agent; synbiotic agent; high density lipoprotein; synbiotic agent; triacylglycerol; very low density lipoprotein, adult; aged; antibiotic therapy; article; bread; controlled study; dyslipidemia; female; human; insulin treatment; Lactobacillus; Lactobacillus sporogenes; lipid blood level; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; randomized controlled trial; blood; diet; double blind procedure; non insulin dependent diabetes mellitus, Lactobacillus sporogenes, Bread; Diabetes Mellitus, Type 2; Diet; Double-Blind Method; Female; Humans; Lipoproteins, HDL; Lipoproteins, VLDL; Male; Middle Aged; Synbiotics; Triglycerides
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 04 Mar 2017 07:18
Last Modified: 04 Mar 2017 07:18

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