The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial

Bahmani, F. and Karamali, M. and Shakeri, H. and Asemi, Z. (2014) The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial. Clinical Endocrinology, 81 (4). pp. 582-587.

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Abstract

Objective: This study was conducted to determine the effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress among women with polycystic ovary syndrome (PCOS). Design, Patients and Measurements: This randomized, double-blind, placebo-controlled clinical trial was conducted among 69 women diagnosed with PCOS and aged 18-40 year old. Participants were randomly assigned to three groups receiving the following: (1) folate-1: 1 mg/d folate supplements (N = 23); (2) folate-5: 5 mg/d folate supplements (N = 23) and (3) placebo (N = 23) for 8 weeks. Fasting blood samples were taken at the beginning of the study and after 8 weeks to measure homocysteine (Hcy), inflammatory factors including high-sensitivity C-reactive protein (hs-CRP), nitric oxide (NO), biomarkers of oxidative stress including total antioxidant capacity (TAC), glutathione (GSH), malondialdehyde (MDA) and homoeostatic model assessment-beta cell function (HOMA-B). Results: Supplementation with 5 mg/d folate resulted in reduced plasma Hcy (-2.23 vs -1.86 and 1.16 μM, respectively, P < 0.05), HOMA-B (-7.63 vs 1.43 and 13.66, respectively, P < 0.05), serum hs-CRP (-212.2 vs -262.4 and 729.8 μg/l, respectively, P < 0.05) and plasma MDA concentrations (-0.48 vs -0.24 and 0.69 μM, respectively, P < 0.01) compared with folate-1 and placebo groups. Furthermore, a significant rise in plasma TAC (0.64 vs -3.53 and -215.47 mM, respectively, P < 0.01) and GSH levels (162.1 vs 195.8 and -158.2 μM, respectively, P < 0.01) was also observed following the administration of 5 mg/d folate supplements compared with folate-1 and placebo groups. Conclusions: In conclusion, folate supplementation (5 mg/d) in women with PCOS had beneficial effects on inflammatory factors and biomarkers of oxidative stress. © 2014 John Wiley & Sons Ltd.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: C reactive protein; folic acid; glutathione; homocysteine; malonaldehyde; nitric oxide; placebo; antioxidant; biological marker; C reactive protein; folic acid; glutathione; malonaldehyde; nitric oxide, adult; Article; blood sampling; body fat distribution; body mass; caloric intake; cell function; controlled study; diet restriction; double blind procedure; female; homoeostatic model assessment beta cell function; human; Iran; major clinical study; obesity; ovary polycystic disease; oxidative stress; randomized controlled trial; therapy effect; total antioxidant capacity; vitamin supplementation; adolescent; blood; drug effects; metabolism; obesity; oxidative stress; Polycystic Ovary Syndrome; young adult, Adolescent; Adult; Antioxidants; Biological Markers; C-Reactive Protein; Double-Blind Method; Female; Folic Acid; Glutathione; Humans; Malondialdehyde; Nitric Oxide; Obesity; Overweight; Oxidative Stress; Polycystic Ovary Syndrome; Young Adult
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 05 Mar 2017 05:16
Last Modified: 05 Mar 2017 05:16
URI: http://eprints.kaums.ac.ir/id/eprint/519

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