Vitamin D supplementation restores suppressed synaptic plasticity in Alzheimer's disease

Taghizadeh, M. and Talaei, S.A. and Djazayeri, A. and Salami, M. (2014) Vitamin D supplementation restores suppressed synaptic plasticity in Alzheimer's disease. Nutritional Neuroscience, 17 (4). pp. 172-177.

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Objectives: Hippocampus, an appropriate area of brain for assessment of long-term potentiation (LTP), has been found to be susceptible to neural damages caused by Alzheimer's disease. Evidence indicates that vitamin D supports nerve transmission and synaptic plasticity. Vitamin D receptors are expressed in the hippocampus. Methods: The present study evaluates occurrence of LTP in the control (CON) group fed with normal regimen and, three groups of Aβ-treated rats taking normal (ALZ), vitamin D-free (ALZ - D), or 1, 25(OH)2D3 supplemented (ALZ + D) food regimens. In in vivo experiments pre- and post-tetanus field extracellular postsynaptic potentials (fEPSPs) were recorded in the CA3-CA1 pathway. Results: We found that the amplitude of baseline fEPSPs was significantly lower in the ALZ group compared with the CON one, lack of vitamin D further declined the amplitude of responses in the ALZ - D animals. While the tetanic stimulation elicited a considerable LTP in the CON rats it was failed to induce LTP in the ALZ animals. Furthermore, the tetanus considerably depressed the amplitude of recordings in the ALZ - D group. 1, 25(OH)2D3 supplementation restored post-tetanus potentiation of fEPSPs amplitude in the ALZ + D groups. Discussion: The present findings signify the crucial role of vitamin D on the basic synaptic transmission and synaptic plasticity. © W. S. Maney & Son Ltd 2014.

Item Type: Article
Additional Information: cited By 9
Uncontrolled Keywords: vitamin D; vitamin D, Alzheimer disease; animal experiment; animal model; article; controlled study; long term potentiation; male; nerve cell plasticity; nonhuman; postsynaptic potential; priority journal; rat; synaptic transmission; vitamin supplementation; Alzheimer disease; animal; diet supplementation; disease model; drug effects; hippocampus; nerve cell plasticity; Wistar rat, Alzheimer Disease; Animals; Dietary Supplements; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Male; Neuronal Plasticity; Rats; Rats, Wistar; Synaptic Transmission; Vitamin D
Subjects: Neuroscience
Divisions: Faculty of Medicine > Basic Sciences > Department of physiology
Depositing User: editor . 2
Date Deposited: 04 Mar 2017 07:41
Last Modified: 04 Mar 2017 07:41

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