Hemostatic effect of aluminum chloride in liver bleeding: An animal model study

Nouri, S. and Sharif, M.R. (2014) Hemostatic effect of aluminum chloride in liver bleeding: An animal model study. Tehran University Medical Journal, 72 (7). pp. 435-442.

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Background: Controlling parenchymal hemorrhage especially in liver parenchyma, despite all the progress in surgical science, is still one of the challenges surgeons face saving patients� lives and there is a research challenge among researchers in this field to introduce a more effective method. This study attempts to determine the haemostatic effect of aluminum chloride and compare it with that of the standard method (simple suturing technique) in controlling bleeding from liver parenchymal tissue. Methods: This is an experimental study. In this animal model study 60 male Wistar rats were randomly allocated into six groups and each of which contains 10 mouse. An incision, two centimeters (cm) long and half a cm deep, was made on each rat�s liver and the hemostasis time was measured once using aluminum chloride with different concentrations (5, 10, 15, 25, and 50) and then using the control method (i.e. controlling bleeding by simple suturing). The liver tissue was examined for pathological changes. Finally, the obtained data were entered into SPSS software and analyzed using Kruskal- wallis test, Mann- Whitney, Kolmogorov- Smirnov test. Results: The mean time to hemostasis in groups of aluminum chloride concentration of 50, 25, 15, 10 and 5 were respectively, 8.90, 13.10, 23.30, 30.30 and 37.8 seconds, also in the control group (suture) mean time of hemostasis was 60/81 seconds. The haemostatic times of different concentrations of aluminum chloride were significantly less than that of the control group (P< 0.001). There was a statistically significant difference between every two haemostatic times (P< 0.001). The pathologic examination showed the highest frequency of low grade inflammation based on the defined pathological grading. Conclusion: Aluminum chloride compare to the control method (i.e. controlling liver bleeding by simple suturing) needs less time to control liver bleeding. Aluminum chloride is an effective agent in controlling liver hemorrhage in an animal model. © 2014 Tehran University of Medical Sciences (TUMS). All rights reserved.

Item Type: Article
Additional Information: cited By 5
Uncontrolled Keywords: aluminum chloride, animal model; animal tissue; Article; controlled study; experimental study; hemostasis; inflammation; liver hemorrhage; male; mouse; nonhuman; pathology; rat; suturing method
Subjects: Physiology
Divisions: Faculty of Medicine > Clinical Sciences > Department of Pediatrics
Depositing User: editor . 2
Date Deposited: 05 Mar 2017 08:37
Last Modified: 05 Mar 2017 08:37
URI: http://eprints.kaums.ac.ir/id/eprint/509

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