The therapeutic potential of quercetin in parkinson�s disease: Insights into its molecular and cellular regulation

Tamtaji, O.R. and Hadinezhad, T. and Fallah, M. and Shahmirzadi, A.R. and Taghizadeh, M. and Behnam, M. and Asemi, Z. (2020) The therapeutic potential of quercetin in parkinson�s disease: Insights into its molecular and cellular regulation. Current Drug Targets, 21 (5). pp. 509-518.

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Parkinson�s disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is a multifactorial disorder, with several different factors being suggested to play a synergistic pathophysiological role, including oxidative stress, autophagy, underlying pro-inflammatory events and neurotransmitters abnormalities. Overall, PD can be viewed as the product of a complex interaction of environmental factors acting on a given genetic background. The importance of this subject has gained more attention to discover novel therapies to prevent as well as treat PD. According to previous research, drugs used to treat PD have indicated significant limitations. Therefore, the role of flavonoids has been extensively studied in PD treatment. Quercetin, a plant flavonol from the flavonoid group, has been considered as a supplemental therapy for PD. Quercetin has pharmacological functions in PD by controlling different molecular pathways. Although few studies intended to evaluate the basis for the use of quercetin in the context of PD have been conducted so far, at present, there is very little evidence available addressing the underlying mechanisms of action. Various principal aspects of these treatment procedures remain unknown. Here, currently existing knowledge supporting the use of quercetin for the clinical management of PD has been reviewed. © 2020 Bentham Science Publishers.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: alpha synuclein; interleukin 1beta; interleukin 6; interleukin 8; neurotransmitter; quercetin; tumor necrosis factor, apoptosis; autophagy (cellular); cytokine release; drug efficacy; environmental factor; human; neurotransmitter release; nonhuman; outcome assessment; oxidative stress; Parkinson disease; pathophysiology; Short Survey; survival analysis
Subjects: Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: ART . editor
Date Deposited: 24 Jun 2020 09:20
Last Modified: 24 Jun 2020 09:20

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