Hamidi, G.A. and Jafari-Sabet, M. and Abed, A. and Mesdaghinia, A. and Mahlooji, M. and Banafshe, H.R. (2014) Gabapentin enhances anti-nociceptive effects of morphine on heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain. Iranian Journal of Basic Medical Sciences, 17 (10). pp. 753-759.
Full text not available from this repository.Abstract
Objective(s): Neuropathic pain is caused by lesions or diseases affecting the somatosensory system and often responds poorly to typical medications. In this study, we evaluated anti-nociceptive effects of morphine, gabapentin and their combination on heat hyperalgesia, cold and mechanical allodynia in chronic constriction injury (CCI) model of neuropathic pain in rats. Materials and Methods: Morphine (2, 4 and 8 mg/kg) and gabapentin (5, 10 and 20 mg/kg) were administered either alone or in combination (morphine 2 mg/kg and gabapentin 5 mg/kg). Results: Our results showed that morphine and gabapentin alone produce anti-nociceptive effects at higher doses (morphine 4 and 8 mg/kg and gabapentin 10 and 20 mg/kg) whereas their combination resulted in better analgesia at lower doses as compared to other treatment groups (morphine 2 mg/kg or gabapentin 5 mg/kg). Conclusion: These findings suggest that gabapentin potentiates the analgesic effects of morphine in the chronic constriction injury (CCI) model of neuropathic pain and combination of these drugs may be considered as a beneficial treatment for neuropathic pain. © 2014, Mashhad University of Medical Sciences. All rights reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 4 |
| Uncontrolled Keywords: | gabapentin; morphine, acetone test; animal experiment; animal model; Article; cold allodynia; controlled study; experimental behavioral test; experimental pain test; heat hyperalgesia; hyperalgesia; male; mechanical hyperalgesia; neuropathic pain; nociception; nonhuman; pain threshold; partial sciatic nerve ligation injury; plantar test; rat; von Frey test |
| Subjects: | Physiology Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Faculty of Medicine > Basic Sciences > Department of Pharmacology |
| Depositing User: | editor . 2 |
| Date Deposited: | 05 Mar 2017 08:05 |
| Last Modified: | 11 Mar 2017 13:51 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/501 |
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