The effects of melatonin on signaling pathways and molecules involved in glioma

Neamati, F. and Asemi, Z. (2020) The effects of melatonin on signaling pathways and molecules involved in glioma. Fundamental and Clinical Pharmacology, 34 (2). pp. 192-199.

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Glioblastoma is one of the most common brain tumors with high invasion and malignancy. Despite extensive research in this area and the use of new and advanced therapies, the survival rate in this disease is very low. In addition, resistance to treatment has also been observed in this disease. One of the reasons for rapid progression and failure in treatment for this disease is the presence of a class of cells with high proliferation and high differentiation, a class called glioblastoma stem-like cells shown as being the source of glioblastoma tumors. It has been reported that several oncogenes are expressed in this disease. One important issue in recognizing the pathogenesis of this disease, and which could improve the treatment process, is the identification of involved oncogenes as well as molecules that affect the reduction of the expression of these oncogenes. Melatonin regulates the biological rhythm and inhibits the proliferation of malignant glioma cells due to antioxidant and anti-apoptotic effects. Melatonin has been considered in biological processes and in signaling pathways involved in the development of glioma. The aim of this review is to investigate the effects of melatonin on signaling pathways and molecules involved in the progression of glioma. © 2019 Société Française de Pharmacologie et de Thérapeutique

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: ABC transporter; estrogen; focal adhesion kinase; focal adhesion kinase 2; gelatinase A; hypoxia inducible factor 1alpha; immunoglobulin enhancer binding protein; integrin; matrix metalloproteinase; melatonin; microRNA; Myc protein; nestin; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; protein bcl 2; protein kinase B; protein kinase C; reactive oxygen metabolite; STAT3 protein; transcription factor EZH2; tumor necrosis factor related apoptosis inducing ligand; vasculotropin, cancer growth; estrogen synthesis; glioma; human; nonhuman; priority journal; Review; signal transduction
Subjects: Neuroscience
Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: ART . editor
Date Deposited: 27 Jun 2020 11:00
Last Modified: 27 Jun 2020 11:00

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