Sadeghi Bimorgh, M. and Omidi, A. and Ghoreishi, F.S. and Rezaei Ardani, A. and Ghaderi, A. and Banafshe, H.R. (2020) The Effect of Transcranial Direct Current Stimulation on Relapse, Anxiety, and Depression in Patients With Opioid Dependence Under Methadone Maintenance Treatment: A Pilot Study. Frontiers in Pharmacology, 11.
|
Text
fphar-11-00401(1).pdf Download (717kB) | Preview |
Abstract
Background and Objective: Patients under methadone maintenance therapy (MMT) are susceptible to several complications including mental disturbances and risk of relapse. The present study was designed to evaluate the effects of tDCS on relapse, depression, and anxiety of opioid-dependent patients under methadone maintenance treatment (MMT). Methods: It was a randomized-clinical trial that conducted among 27 male patients referred to the outpatient addiction clinic of Ibn-e-Sina psychiatric hospital in Mashhad from July 2018 to May 2019. Participants were allocated to two treatment groups including intervention and sham groups. The intervention group received seven sessions of tDCS, in the F3 (cathode) and F4 (anode) areas of the brain, each one lasts 20 min, in two consecutive weeks. Depression, anxiety, and stress scale-21 (DASS-21) were measured before, during, and after the intervention in patients under MMT. Relapse on the morphine, cannabis, and methamphetamine was screened by urine dipstick tests of morphine, cannabis, and methamphetamine. Results: Depression, anxiety, and stress of participants were significantly reduced in the intervention group compared with the control after the seventh session of tDCS (P < 0.001, P=0.01, and P=0.01, respectively). In addition, the relapse rate showed no significant changes between the two groups (P=0.33). Conclusion: Overall, our study demonstrated that depression, anxiety, and stress of participants were significantly reduced after the seventh session of tDCS, but did not affect on the relapse rate. Therefore, it can be applied as a safe and effective technique to relieve mental disorder among receiving MMT. Clinical Trial Registration: http://www.irct.ir, identifier IRCT20180604039979N1. © Copyright © 2020 Sadeghi Bimorgh, Omidi, Ghoreishi, Rezaei Ardani, Ghaderi and Banafshe.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | cannabis; methadone; methamphetamine; morphine, adult; anxiety disorder; Article; brain region; clinical article; clinical effectiveness; clinical evaluation; clinical outcome; controlled study; depression; Depression Anxiety Stress Scale; disease duration; double blind procedure; drug efficacy; drug screening; evidence based practice; human; male; opiate addiction; outpatient care; patient referral; patient safety; pilot study; randomized controlled trial; recurrence risk; risk reduction; therapy effect; transcranial direct current stimulation; treatment duration |
| Subjects: | Medicine Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Faculty of Medicine > Clinical Sciences > Department of Psychiatry |
| Depositing User: | ART . editor |
| Date Deposited: | 27 Jun 2020 10:08 |
| Last Modified: | 27 Jun 2020 10:08 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/4934 |
Actions (login required)
 |
View Item |
