The potential role of chitosan-based nanoparticles as drug delivery systems in pancreatic cancer

Sadoughi, F. and Mansournia, M.A. and Mirhashemi, S.M. (2020) The potential role of chitosan-based nanoparticles as drug delivery systems in pancreatic cancer. IUBMB Life, 72 (5). pp. 872-883.

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Pancreatic cancer (PC) is one of the most lethal cancers and 12th most common cancer in the world. Due to the inaccessible anatomical position of the pancreas and asymptomatic early stages of this disease, PC has a high mortality rate. Therefore, providing reliable diagnostic and therapeutic tools are the keys to increase the PC survival rate. Nanotechnology is an inchoate field of science that previously scientists' tendency to enhance the efficacy of current preventive, diagnostic, and therapeutic methods has oriented them to build a bridge between this science and medicine. In the case of PC, nanotechnology suggests using drug delivery devices for a more effective and targeted therapy. Chitosan is a natural polymer that recently has attracted a lot of attention for being renewable, nontoxic, and bioabsorbable. In this article, we tend to look for the answer to this question: has nanotechnology been successful in using chitosan-based nanoformulations as carriers for preventing more individuals from suffering or at least increasing the 5-year survival of the PC patients?. © 2020 International Union of Biochemistry and Molecular Biology

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: antineoplastic agent; antioxidant; bortezomib; carboplatin; chitosan nanoparticle; cisplatin; curcumin; DNA vaccine; doxorubicin; ferulic acid; fluorouracil; folic acid; gemcitabine; genistein; gold nanoparticle; graphene oxide; macrogol; monoclonal antibody; nanocarrier; oligosaccharide; oxaliplatin; paclitaxel; photosensitizing agent; polymer; polysaccharide; quercetin; silica nanoparticle; small interfering RNA; solid lipid nanoparticle; sulforaphane, drug delivery system; drug formulation; molecular biology; nanotechnology; pancreas adenocarcinoma; pancreas cancer; Review
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: ART . editor
Date Deposited: 27 Jun 2020 11:45
Last Modified: 27 Jun 2020 11:45

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