The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review

Najafi, M. and Hooshangi Shayesteh, M.R. and Mortezaee, K. and Farhood, B. and Haghi-Aminjan, H. (2020) The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review. Life Sciences, 241.


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Purpose: Doxorubicin, as an effective chemotherapeutic drug, is commonly used for combating various solid and hematological tumors. However, doxorubicin-induced cardiotoxicity is considered as a serious adverse effect, and it limits the clinical use of this chemotherapeutic drug. The use of melatonin can lead to a decrease in the cardiotoxic effect induced by doxorubicin. The aim of this review was to evaluate the potential role of melatonin in the prevention of doxorubicin-induced cardiotoxicity. Methods: This review was conducted by a full systematic search strategy based on PRISMA guidelines for the identification of relevant literature in the electronic databases of PubMed, Web of Science, Embase, and Scopus up to January 2019 using search terms in the titles and abstracts. 286 articles were screened in accordance with our inclusion and exclusion criteria. Finally, 28 articles were selected in this systematic review. Results: The findings demonstrated that doxorubicin-treated groups had increased mortality, decreased body weight and heart weight, and increased ascites compared to the control groups; the co-administration of melatonin revealed an opposite pattern compared to the doxorubicin-treated groups. Also, this chemotherapeutic agent can lead to biochemical and histopathological changes; as for most of the cases, these alterations were reversed near to normal levels (control groups) by melatonin co-administration. Melatonin exerts these protection effects through mechanisms of anti-oxidant, anti-apoptosis, anti-inflammatory, and mitochondrial function. Conclusion: The results of this systematic review indicated that co-administration of melatonin ameliorates the doxorubicin-induced cardiotoxicity. © 2019 Elsevier Inc.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: doxorubicin; melatonin, antiapoptotic activity; antiinflammatory activity; antioxidant activity; ascites; body weight loss; cardiotoxicity; drug mechanism; heart protection; heart weight; histopathology; mitochondrion; mortality; nonhuman; Review; systematic review
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: ART . editor
Date Deposited: 07 Jan 2020 12:19
Last Modified: 07 Jan 2020 12:19

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