Genetic and epigenetic contribution to astrocytic gliomas pathogenesis

Khani, P. and Nasri, F. and Khani Chamani, F. and Saeidi, F. and Sadri Nahand, J. and Tabibkhooei, A. and Mirzaei, H. (2019) Genetic and epigenetic contribution to astrocytic gliomas pathogenesis. Journal of Neurochemistry, 148 (2). pp. 188-203.

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Astrocytic gliomas are the most common and lethal form of intracranial tumors. These tumors are characterized by a significant heterogeneity in terms of cytopathological, transcriptional, and (epi)genomic features. This heterogeneity has made these cancers one of the most challenging types of cancers to study and treat. To uncover these complexities and to have better understanding of the disease initiation and progression, identification, and characterization of underlying cellular and molecular pathways related to (epi)genetics of astrocytic gliomas is crucial. Here, we discuss and summarize molecular and (epi)genetic mechanisms that provide clues as to the pathogenesis of astrocytic gliomas. (Figure presented.). © 2018 International Society for Neurochemistry

Item Type: Article
Additional Information: cited By 17
Uncontrolled Keywords: epidermal growth factor receptor; isocitrate dehydrogenase; methylated DNA protein cysteine methyltransferase; microRNA; protein MDM2; protein p53; temozolomide, astrocytic glioma; astrocytoma; DMBT1 gene; EGFR gene; epigenetics; gene; gene amplification; gene deletion; gene mutation; gene rearrangement; genetic risk; glioblastoma; glioma; histopathology; human; IDH gene; MDM2 gene; MGMT gene; molecular genetics; P53 gene; pathogenesis; priority journal; Review; animal; astrocytoma; brain tumor; genetic epigenesis; genetics; pathology, Animals; Astrocytoma; Brain Neoplasms; Epigenesis, Genetic; Humans
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Applied Cell Sciences
Depositing User: ART . editor
Date Deposited: 24 Dec 2019 12:12
Last Modified: 24 Dec 2019 12:12

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