The effects of Vitamin D supplementation on glycemic control, lipid profiles and c-reactive protein among patients with cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials

Ostadmohammadi, V. and Milajerdi, A. and Ghayour-Mobarhan, M. and Ferns, G. and Taghizadeh, M. and Badehnoosh, B. and Mirzaei, H. and Asemi, Z. (2019) The effects of Vitamin D supplementation on glycemic control, lipid profiles and c-reactive protein among patients with cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials. Current Pharmaceutical Design, 25 (2). pp. 201-210.

Full text not available from this repository.
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....
DOI: UNSPECIFIED

Abstract

Background: Insulin resistance, dyslipidemia and chronic inflammation are important risk factors for cardiovascular diseases (CVD). Hence, vitamin D supplementation might be an appropriate approach to decrease the complications of CVD. This systematic review and meta-analysis aimed to determine the effects of vitamin D supplementation on glycemic control, lipid profiles, and C-reactive protein among patients with coronary artery disease. Methods: Two independent authors systematically searched online databases including EMBASE, Scopus, Pub- Med, Cochrane Library, and Web of Science until 20th September 2018. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of included trials. The heterogeneity among the included studies was assessed using Cochran�s Q test and I-square (I2) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Results: A total of eight trials (305 participants in the intervention group and 325 in placebo group) were included in the current meta-analysis. Pooling effect sizes from studies revealed a significant reduction in fasting glucose (WMD): -15.67; 95 CI: -29.32, -2.03), insulin concentrations (WMD: -3.53; 95 CI: -4.59, -2.46) and homeostatic model assessment of insulin resistance (WMD: -1.07; 95 CI: -1.49, -0.66), and significant increase in the quantitative insulin-sensitivity check index (WMD: 0.02; 95 CI: 0.01, 0.03) following the administration of vitamin D. In addition, pooled analysis revealed a significant increase in serum HDL-cholesterol concentrations following vitamin D therapy (WMD: 3.08; 95 CI: 1.42, 4.73). Additionally, vitamin D supplementation significantly reduced C-reactive protein (CRP) levels (WMD: -0.75; 95 CI: -1.28, -0.23). Conclusion: This meta-analysis demonstrated the beneficial effects of vitamin D supplementation on improving glycemic control, HDL-cholesterol and CRP levels among patients with CVD, though it did not affect triglycerides, total- and LDL-cholesterol levels. © 2019 Bentham Science Publishers.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: C reactive protein; high density lipoprotein cholesterol; low density lipoprotein cholesterol; vitamin D, age distribution; Article; cholesterol blood level; coronary artery disease; drug efficacy; drug response; glycemic control; homeostasis model assessment; human; insulin sensitivity; outcome assessment; priority journal; systematic review; treatment duration; treatment outcome; vitamin supplementation
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 24 Dec 2019 16:03
Last Modified: 24 Dec 2019 16:03
URI: http://eprints.kaums.ac.ir/id/eprint/4813

Actions (login required)

View Item View Item