A pilot study to evaluate the effects of oral N-acetyl cysteine on inflammatory and oxidative stress biomarkers in rheumatoid arthritis

Hashemi, G. and Mirjalili, M. and Basiri, Z. and Tahamoli-Roudsari, A. and Kheiripour, N. and Shahdoust, M. and Ranjbar, A. and Mehrpooya, M. and Ataei, S. (2019) A pilot study to evaluate the effects of oral N-acetyl cysteine on inflammatory and oxidative stress biomarkers in rheumatoid arthritis. Current Rheumatology Reviews, 15 (3). pp. 246-253.

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Background: Rheumatoid Arthritis (RA) is a common inflammatory disease of the joints. Due to the importance of inflammation and oxidative stress in the pathogenesis of RA, drugs that have anti-oxidant and anti-inflammatory properties, such as N-acetyl Cysteine (NAC), can be used as adjunctive therapy in patients with RA. Aims: The aim of this study was to evaluate the effects of oral NAC on inflammatory cytokines and oxidative stress in patients with RA. Methods: Adjunct to standard treatment, the NAC group (23 patients) received 600 mg of NAC twice daily and the placebo group (19 patients) received identical placebo twice daily for 12 weeks. Serum levels of Total Oxidant Status (TOS), Total Antioxidant Capacity (TAC), nitric oxide (NO), Total Thiol Groups (TTG), Malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive Protein (CRP), and Erythrocyte Sedimentation Rate (ESR) were measured at baseline and at the end of the study. Results: Results showed that in the NAC group, the serum levels of MDA, NO, IL-6, TNF-α, ESR and CRP were significantly lower than the baseline. Also, the serum level of TAC and TTG, as antioxidant parameters, increased significantly. However, only NO, MDA and TTG showed a significant difference in the NAC group �as compared to the placebo group at the end of study. Conclusion: According to the results of this study, oral NAC can significantly reduce the several oxidative stress factors and inflammatory cytokines. These results need to be confirmed in larger studies while considering clinical outcomes of RA patients. © 2019 Bentham Science Publishers.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: acetylcysteine; antioxidant; biological marker; C reactive protein; calcium plus colecalciferol; folic acid; hydroxychloroquine; interleukin 6; malonaldehyde; methotrexate; nitric oxide; nonsteroid antiinflammatory agent; oxidizing agent; placebo; prednisolone; salazosulfapyridine; thiol; tumor necrosis factor, adult; antiinflammatory activity; antioxidant activity; Article; clinical article; colorimetry; controlled study; disease activity score; double blind procedure; enzyme linked immunosorbent assay; erythrocyte sedimentation rate; female; ferric reducing antioxidant power assay; human; inflammation; male; oxidative stress; pilot study; priority journal; randomized controlled trial; rheumatoid arthritis; spectrofluorometry; clinical trial
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Internal Medicine
Depositing User: ART . editor
Date Deposited: 24 Dec 2019 16:01
Last Modified: 24 Dec 2019 16:01
URI: http://eprints.kaums.ac.ir/id/eprint/4812

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