The effects of quercetin supplementation on blood pressures and endothelial function among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials

Tamtaji, O.R. and Milajerdi, A. and Dadgostar, E. and Kolahdooz, F. and Chamani, M. and Amirani, E. and Mirzaei, H. and Asemi, Z. (2019) The effects of quercetin supplementation on blood pressures and endothelial function among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials. Current Pharmaceutical Design, 25 (12). pp. 1372-1384.

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Abstract

Background: This systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to determine the effect of quercetin administration on blood pressures and endothelial function among patients with metabolic syndrome (MetS) and related disorders. Methods: We searched systematically online databases including Cochrane Library, EMBASE, MEDLINE, and Web of Science to identify the relevant RCTs until December 2018. Q-test and I2 statistics were applied to assess heterogeneity among the included studies. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Results: Out of 284 citations, 8 RCTs were included in the meta-analysis. We found a significant reduction in systolic blood pressure (SBP) (WMD:-1.69; 95 CI:-3.22,-0.17) following the intake of quercetin supplements. However, quercetin supplementation did not significantly affect diastolic blood pressure (DBP) (WMD:-3.14; 95 CI:-8.24, 1.95), vascular cell adhesion molecule 1 (VCAM-1) (WMD:-24.49; 95 CI:-53.74, 4.77) and intercellular adhesion molecule 1 (ICAM-1) (WMD:-5.78; 95 CI:-12.93, 1.38). Conclusion: In summary, the current meta-analysis demonstrated that quercetin supplementation significantly reduced SBP, yet did not affect DBP, VCAM-1 and ICAM-1 among patients with MetS and related disorders. © 2019 Bentham Science Publishers.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: intercellular adhesion molecule 1; quercetin; vascular cell adhesion molecule 1, blood pressure; cardiovascular function; data base; data extraction; data synthesis; diastolic blood pressure; diet supplementation; effect size; human; meta analysis; metabolic syndrome X; priority journal; publication bias; quality control; randomized controlled trial (topic); Review; statistical analysis; systematic review; systolic blood pressure; treatment duration; vascular endothelium
Subjects: Medicine
Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 28 Dec 2019 15:10
Last Modified: 28 Dec 2019 15:10
URI: http://eprints.kaums.ac.ir/id/eprint/4803

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